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Cellular reprogramming as a tool to model human aging in a dish

Pitrez, Patrícia R.; Monteiro, Luís M.; Borgogno, Oliver; Nissan, Xavier; Mertens, Jerome; Ferreira, Lino

The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our un...


On performance of distributed model predictive control in power system frequenc...

Monteiro, Luís M.; Igreja, José

This paper describes the implementation of a distributed model predictive approach for automatic generation control. Performance results are discussed by comparing classical techniques (based on integral control) with model predictive control solutions (centralized and distributed) for different operational scenarios with two interconnected networks. These scenarios include variable load levels (ranging from a ...


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