14 documents found, page 1 of 2
K+ATP channels-independent analgesic action of Crotalus durissus cumanensis venom
Pereira, Ticiana Praciano; Campos, Adriana Rolim; Leal, Luzia Kalyne A. M.; Pierdoná, Taiana Magalhães; Toyama, Marcos H. [UNESP]Made available in DSpace on 2022-04-28T21:24:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01; The effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 μg/kg) produced an antinociceptive effect durin...
Hydrogel and membrane scaffold formulations of Frutalin (breadfruit lectin) wit...
Sousa, Felipe Domingos de; Vasconselos, Pedrinha Diógenes; Silva, Ayrles Fernanda Brandão da; Mota, Erika Freitas; Tomé, Adriana da RochaPlant lectins are carbohydrate-binding proteins, which can interact with cell surfaces to initiate anti-inflammatory pathways, as well as immunomodulatory functions. Here, we have extracted, purified and part-characterized the bioactivity of Jacalin, Frutalin, DAL and PNA, before evaluating their potential for wound healing in cultured human skin fibroblasts. Only Frutalin stimulated fibroblast migration in vit...
Functional capacity as a predictor of postoperative delirium in transurethral r...
Sampaio, Ianna Lacerda; Castelo-Filho, João; Sousa, Rafael de; Pinheiro, Bezerra; Azevedo, Rodrigo Barbosa de; Ponte, Antônio TalysIntroduction: Postoperative delirium (POD) is a common disorder and its frequency varies from 15% to 25% after major elective surgery. There are few data on the incidence of POD in Brazil. Here, we sought to assess the incidence of POD following transurethral resection of the prostate (TURP) and to examine precipitating and predisposing factors associated. Method: We performed a prospective observational study ...
Use of medicinal plants by patients with hypertension and diabetes: a cross-sec...
Virgínio, Taís Batista; Castro, Karla Soares de; Lima, Ana Luiza Almeida de; Rocha, Juliana Vieira; Bonfim, Isabela Melo; Campos, Adriana RolimObjective: To describe the use of medicinal plants by hypertensive and/or diabetic patients served by primary health care centers and at a specialized outpatient clinic. Methods: A quantitative, descriptive, exploratory and cross-sectional study was carried out with 122 participants in 16 Primary Health Care Centers run by the VI Regional Executive Secretariat and at a specialized outpatient clinic of the Walte...
Gastroprotective and anti-inflammatory activities integrated to chemical compos...
Galvão, Wellyda Rocha Aguiar; Braz Filho, R.; Canuto, K. M.; Ribeiro, P. R. V.; Campos, Adriana Rolim; Moreira, A. C. O. M.; Silva, S. O.Ethnopharmacological relevance: Myracrodruon urundeuva Allemão (Aroeira-do-Sertão), Anacardiaceae, is one of the most used plants in folk medicine in Northeastern Brazil as an anti-inflammatory, healing and antiulcer. This species is threatened with extinction due to anthropogenic exploitation. The importance of this study is to demonstrate the feasibility of a conservationist model of replacement of the M. uru...
Acute and neuropathic orofacial antinociceptive effect of eucalyptol
Melo Júnior, José de Maria de Albuquerque de; Damasceno, Marina de Barros Mamede Vidal; Santos, Sacha Aubrey Alves Rodrigues; Barbosa, Talita MatiasTerpenes have a wide range of pharmacological properties, including antinociceptive action. The anti-in- flammatory and antinociceptive effects of eucalyptol are well established. The purpose of this study was to evaluate the antinociceptive effect of eucalyptol on acute and neu- ropathic orofacial pain in rodent models. Acute orofacial and corneal nociception was induced with formalin, cap- saicin, glutamate a...
Phytochemical analysis and modulation in aminoglycosides antibiotics activity b...
Sousa, Erlânio Oliveira de; Rodrigues, Fabíola Fernandez Galvão; Campos, Adriana Rolim; Costa, José Galberto Martins daSeveral plants have been evaluated not only for alone antimicrobial activity, but as resistance-modifying agent. This work is the first on the modulation of antibiotic activity by Lantana camara L. extracts against multiresistant strains of Escherichia coli and Staphylococcus aureus. The antibacterial activities of leaf and root ethanol extracts alone or in association with aminoglycosides were determined again...
Topical antinociceptive effect of vanillosmopsis arborea baker on acute corneal...
Leite, Laura Hévila Inocêncio; Leite, Gerlânia de Oliveira; Coutinho, Thales Silva; Sousa, Severino Denício Gonçalves de; Sampaio, Renata SouzaThis study aimed to assess the possible topical antinociceptive activity of Vanillosmopsis arborea Baker essential oil (EOVA) and to clarify the underlying mechanism, using the acute model of chemical (eye wiping) nociception in mice. EOVA (25 to 200mg/kg; p.o. and topical) evidenced significant antinociception against chemogenic pain in the test model of formalin-induced neuroinflammatory pain. Local applicati...
Study of visceral antinociceptive potential of bee Apis mellifera venom
Costa, Marcus F. B.; Campos, Adriana Rolim; Abdon, Ana Paula Vasconcellos; Vasconcelos, Renata P.; Castro, Carolina A.; Toyama, Marcos H.Pain is one of the most common reasons for patients to seek medical care. Bee Apis mellifera venom (AMV) has traditionally been used to treat inflammatory diseases and the alleviation of pain. Herein, we aimed to investigate the visceral antinociceptive potential of A. mellifera bee venom and its possible mechanism of action. Acetic acid-induced writhing assay was used in mice to determine the degree of viscera...
Ethanol-induced gastric injury : microscopic analysis of the protective effect ...
Abdon, Ana Paula Vasconcellos; Vasconcelos, Renata Prado; Castro, Carolina Araújo; Guedes, Marjorie Moreira; Tomé, Adriana da RochaObtained from breadfruit seeds (Artocarpus incisa), frutalin (FTL) has a range of important pharmacological properties. FTL activates and modulates lymphocytes and neutrophils and possesses gastroprotective effects. The purpose of this study was to evaluate the ability of FTL to protect the gastric mucosa of mice submitted to ethanolinduced gastric injury. The gastroprotective effect of frutalina was evaluated ...