16 documents found, page 1 of 2
GLP-1 Increases Circulating Leptin Levels in Truncal Vagotomized Rats
Morais, T; Pereira, SS; Andrade, S; Neves, D; Guimaraes, M; Nora, M; Carreira, MC; Casanueva, FF; Monteiro, MPGLP-1 is a gastro-intestinal hormone acting within the gut/brain axis for energy balance regulation. We aimed to evaluate the role of the vagus nerve in whole-body energy homeostasis and in mediating GLP-1 effects. For this, rats submitted to truncal vagotomy and sham-operated controls underwent a comprehensive evaluation, including eating behavior, body weight, percentage of white (WAT) and brown adipose tissu...
Visceral Adipose Tissue Bioenergetics Varies According to Individuals' Obesity ...
Topete, MV; Andrade, S; Bernardino, RL; Guimaraes, M; Pereira, AM; Oliveira, SB; Costa, MM; Nora, M; Monteiro, MP; Pereira, SSObesity is associated with complex adipose tissue energy metabolism remodeling. Whether AT metabolic reprogramming differs according to body mass index (BMI) and across different obesity classes is unknown. This study's purpose was to evaluate and compare bioenergetics and energy substrate preference of visceral adipose tissue (VAT) pertaining to individuals with obesity class 2 and class 3. VAT obtained from p...
Renal Dysfunction Phenotypes in Patients Undergoing Obesity Surgery
Pereira, PR; Pereira, J; Braga, PC; Pereira, SS; Nora, M; Guimaraes, M; Monteiro, MP; Rodrigues, AObesity surgery candidates are at an increased risk of kidney injury, but pre-operative evaluation usually neglects kidney function assessment. This study aimed to identify renal dysfunction in candidates for bariatric surgery. To reduce the sources of bias, subjects with diabetes, prediabetes under metformin treatment, neoplastic or inflammatory diseases were excluded. Patients' (n = 192) average body mass ind...
Towards precision medicine in bariatric surgery prescription
Pereira, SS; Guimaraes, M; Monteiro, MPObesity is a complex, multifactorial and chronic disease. Bariatric surgery is a safe and effective treatment intervention for obesity and obesity-related diseases. However, weight loss after surgery can be highly heterogeneous and is not entirely predictable, particularly in the long-term after intervention. In this review, we present and discuss the available data on patient-related and procedure-related fact...
Individuals with type 2 diabetes have higher density of small intestinal neurot...
Ferreira, FP; Pereira, SS; Costa, MM; Guimarães, M; Nicolai J Wewer Albrechtsen; Jens J Holst; Mário Nora; Monteiro, MPNeurotensin (NT) is a gastro-intestinal hormone involved in several pathways that regulate energy and glucose homeostasis. NT was hypothesized to act in synergy with incretin hormones to potentiate its anti-diabetic effects. Additionally, circulating NT levels were shown to rise after bariatric surgery-induced weight loss. Knowledge of NT-secreting cells distribution along the small intestine and its variation ...
Congenital Glucagon-like Peptide-1 Deficiency in the Pathogenesis of Protracted...
Nóbrega, S; Monteiro, MP; Pereira-da-Silva, L; Pereira, SS; Hartmann, B; Holst, JJ; Barbosa Silva, R; Cordeiro-Ferreira, GContext: Mitchell-Riley syndrome due to RFX6 gene mutations is characterized by neonatal diabetes and protracted diarrhea. The RFX6 gene encodes a transcription factor involved in enteroendocrine cell differentiation required for beta-cell maturation. In contrast to the pathway by which RFX6 mutations leads to diabetes, the mechanisms underlying protracted diarrhea are unknown. Objective: To assess whether gluc...
Mineralocorticoid receptor antagonists eplerenone and spironolactone modify adr...
Pereira, SS; Carvalho, LS; Costa, MM; Melo, A; Ferreira, IMPLVO; Gomez-Sanchez, CE; Monteiro, MP; Vinson, G; Pignatelli, DMineralocorticoid receptor antagonists (MRAs) are a class of anti-hypertensive drugs that act by blocking aldosterone action. The aim of this study was to evaluate whether the MRAs spironolactone and eplerenone influence adrenal cortical physiology and morphology. Spontaneous hypertensive rats (SHR, n = 18) and normotensive rats (WKY, n = 18) were randomly exposed to a daily dose of spironolactone (n = 6), eple...
Incomplete pattern of steroidogenic protein expression in functioning adrenocor...
Pereira, SS; Costa, MM; Gomez-Sanchez, CE; Monteiro, MP; Pignatelli, DAutonomous steroid secretion is a common feature of adrenocortical carcinomas (ACC), although not always clinically evident owing to inefficient steroidogenesis with increased release of steroid precursors. Our study aim was to analyze the expression profile of four key proteins involved in the steroidogenesis cascade, in different adrenocortical tumors. Expression of proteins involved in steroidogenesis, namel...
A Potential Role for Endogenous Glucagon in Preventing Post-Bariatric Hypoglycemia
Lobato, CB; Pereira, SS; Guimarães, M; Hartmann, B; Wewer Albrechtsen, NJ; Hilsted, L; Holst, JJ; Nora, M; Monteiro, MPObesity and obesity-related diseases are major public health concerns that have been exponentially growing in the last decades. Bariatric surgery is an effective long-term treatment to achieve weight loss and obesity comorbidity remission. Post-bariatric hypoglycemia (PBH) is a late complication of bariatric surgery most commonly reported after Roux-en-Y gastric bypass (RYGB). PBH is the end result of postprand...
Use of flash glucose monitoring for post-bariatric hypoglycaemia diagnosis and ...
Lobato, CB; Pereira, SS; Guimarães, M; Morais, T; Oliveira, P; de Carvalho, JPM; Nora, M; Monteiro, MPOur aim was to assess the potential of flash glucose monitoring (FGM) for diagnostic workup of suspected post-bariatric hypoglycaemia (PBH). Patients (N = 13) with suspected PBH underwent a food and symptoms diary (FSD) record along with FGM over 14 days. Targeted data analysis confirmed the occurrence of low glucose events in parallel to meal-triggered symptoms. Glycaemic variability, as assessed by Mean Absol...