12 documents found, page 1 of 2
Colon tumor CD31 expression is associated with higher disease-free survival in ...
Silva, Ana; Pereira, Sofia S.; Brandão, José Ricardo; Brochado, Paulo; Monteiro, Mariana P.; Araújo, António; Faria, GilMetabolic syndrome (MS) is recognized as a risk factor for colon cancer (CC). However, how does the interplay between metabolic dysfunction caused by MS and its individual components affect CC microenvironment and prognosis remains unexplored. Angiogenesis and lymphangiogenesis are fundamental processes for tumor progression and dissemination, ensuring oxygen and nutrient delivery and supporting one of the most...
Effect of metabolic syndrome and individual components on colon cancer characte...
Silva, Ana; Pereira, Sofia S.; Monteiro, Mariana P.; Araújo, António; Faria, GilMetabolic syndrome (MS) is recognized as a risk factor for colon cancer (CC). However, whether the cluster of metabolic changes that define MS also influence CC prognosis remains unclear. Thus, our aim was to investigate whether the presence of MS or any of the MS individual components could provide prognostic information on tumor phenotype and survival outcomes. Clinical and pathological data from patients wit...
POST-BARIATRIC HYPOGLYCAEMIA: FROM SCIENTIFIC EVIDENCE TO CLINICAL PRACTICE
Lobato, Carolina B.; Monteiro, Mariana P.; Guimarães, MartaApproaching the patient presenting symptoms compatible with post-bariatric hypoglycaemia (PBH) is a major clinical challenge for surgeons, endocrinologists, nutritionists, and primary care physicians. Raising the hypothesis of PBH as differential diagnosis requires a high degree of suspicion, since patient clinical features at presentation are highly unspecific and overlap with those of dumping syndrome, which ...
Impact of adiposity on staging and prognosis of colorectal cancer
Silva, Ana; Faria, Gil; Araújo, António; Monteiro, Mariana P.Abdominal visceral fat is a well-recognized a risk for colorectal cancer (CRC). In contrast to the risk for CRC, the impact of adiposity in disease staging and patient survival is less well-established. Our aim was to critically review the literature on the influence of adiposity assessed by different methods routinely used in clinical settings, on CRC staging and prognosis. In the 32 studies reviewed, overweig...
Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket?
Crisóstomo, Luís; Pereira, Sara C.; Monteiro, Mariana P.; Raposo, João F.; Oliveira, Pedro F.; Alves, Marco G.Hypogonadism is more frequent among men with common metabolic diseases, notably obesity and type 2 diabetes. Indeed, endocrine disruption caused by metabolic diseases can trigger the onset of hypogonadism, although the underlying molecular mechanisms are not entirely understood. Metabolic diseases are closely related to unhealthy lifestyle choices, such as dietary habits and sedentarism. Therefore, hypogonadism...
Metabolic dynamics of human Sertoli cells are differentially modulated by physi...
Martins, Ana D.; Monteiro, Mariana P.; Silva, Branca M.; Barros, Alberto; Sousa, Mário; Carvalho, Rui A.; Oliveira, P.F.; Alves, Marco G.Obesity incidence has pandemic proportions and is expected to increase even further. Glucagon-like peptide-1 (GLP-1) based therapies are well-established pharmacological resources for obesity treatment. GLP-1 regulates energy and glucose homeostasis, which are also crucial for spermatogenesis. Herein, we studied the GLP-1 effects in human Sertoli cells (hSCs) metabolism and mitochondrial function. hSCs were cul...
8-(3-phenylpropyl)-1,3,7-triethylxanthine is a synthetic caffeine substitute wi...
Carrageta, David F; Dias, Tânia R.; Jarak, Ivana; Alves, Marco G; Oliveira, P.F.; Walt, Mietha Van Der; Terre'Blanche, Gisella; Monteiro, Mariana P.Caffeine is one of the most worldwide consumed methylxanthines. It is well-known for its thermogenic and cell metabolism modulating effects. Based on methylxanthines' chemical structure, 8-(3-phenylpropyl)-1,3,7-triethylxanthine (PTX) is a novel adenosine antagonist with higher receptor affinity than caffeine. Therefore, we hypothesized that PTX metabolic effects could be stronger than those of caffeine. For th...
Ação da leptina no metabolismo da glucose das células de Sertoli: impacto na fe...
Martins, Ana D.; Moreira, Ana C.; Sá, Rosália; Monteiro, Mariana P.; Sousa, Mário; Carvalho, Rui A.; Silva, Branca M.; Oliveira, Pedro F.Nos últimos anos os hábitos alimentares e o estilo de vida têm vindo a tornar-se pouco saudáveis, favorecendo o desenvolvimento de doenças metabólicas (por exemplo Diabetes tipo 2 e obesidade). A leptina é uma hormona produzida no tecido adiposo responsável pela sensação de saciedade. Os níveis desta hormona estão positivamente relacionados com a quantidade de gordura corporal e têm sido descritos efeitos negat...
Adipocyte Secreted Factors Enhance Aggressiveness of Prostate Carcinoma Cells
Moreira, Ângela; Pereira, Sofia S.; Costa, Madalena; Morais, Tiago; Pinto, Ana; Fernandes, Rúben; Monteiro, Mariana P.Obesity has been associated with increased incidence and risk of mortality of prostate cancer. One of the proposed mechanisms underlying this risk association is the change in adipokines expression that could promote the development and progression of the prostate tumor cells. The main goal of this study was to evaluate the effect of preadipocyte and adipocyte secretome in the proliferation, migration and invas...
Adenomiose da papila de Vater
Guimarães, Marta; Rodrigues, Pedro; Gonçalves, Gil; Oliveira, Vera; Nora, Mário; Monteiro, Mariana P.Introdução: Os tumores benignos da papila são pouco frequentes e de entre estes a adenomiose têm uma incidência rara. A importância destas lesões prende-se com o facto de poderem ser causa de icterícia obstrutiva e com a possibilidade de se tratarem de lesões pré-malignas.Caso clínico: Doente do sexo feminino, 75 anos de idade, submetida a duodenopancreatectomia cefálica por nódulo sólido cefalopancreático dete...