26 documents found, page 1 of 3
Measuring adherence to inhaled control medication in patients with asthma: Comp...
Cachim, Afonso; Pereira, Ana Margarida; Almeida, Rute; Amaral, Rita; Correia, Magna Alves; Marques, Pedro Vieira; Loureiro, Cláudia ChavesBackground Previous studies have demonstrated the feasibility of using an asthma app to support medication management and adherence but failed to compare with other measures currently used in clinical practice. However, in a clinical setting, any additional adherence measurement must be evaluated in the context of both the patient and physician perspectives so that it can also help improve the process of shared...
Symptoms of anxiety and depression in patients with persistent asthma: a cross-...
Cunha, Mafalda Simões; Amaral, Rita; Pereira, Ana Margarida; Almeida, Rute; Alves-Correia, Magna; Loureiro, Cláudia Chaves; Lopes, CristinaAnxiety and depression are relevant comorbidities in asthma, but, in Portugal and Spain, data on this topic are scarce. We assessed, in patients with asthma, the frequency of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and the European Quality of Life Five Dimension Questionnaire (EQ-5D); the level of agreement between these questionnaires, and the factors associated with thes...
Tailoring gut microbiota with a combination of vitamin K and probiotics as a po...
Pereira, Luciana; Monteiro, RosárioSummary Rheumatoid arthritis (RA) is an autoimmune disease of multifactorial etiology, characterised by a chronic inflammatory reaction of the joints, but can also affect other tissues. Some environmental factors can trigger an immune system response in genetically susceptible individuals, activating the disease. Lower diversity of gut microbiota, and dysbiosis, have been observed in RA patients. In this regard...
Physical exercise positively modulates nonalcoholic steatohepatitis‐related hep...
Passos, Emanuel; Pereira, Cidália; Gonçalves, Inês O.; Faria, Ana; Ascensão, António; Monteiro, Rosário; Magalhães, José; Martins, Maria J.Obesity is a predictive factor for the development of nonalcoholic steatohepatitis (NASH). Although some of the mechanisms associated with NASH development are still elusive, its pathogenesis relies on a complex broad spectrum of (interconnected) metabolic-based disorders. We analyzed the effects of voluntary physical activity (VPA) and endurance training (ET), as preventive and therapeutic nonpharmacological s...
Gut Microbiota, in the Halfway between Nutrition and Lung Function
Espirito Santo, Christophe; Caseiro, Catarina; Martins, Maria João; Monteiro, Rosário; Brandão, InêsThe gut microbiota is often mentioned as a "forgotten organ" or "metabolic organ", given its profound impact on host physiology, metabolism, immune function and nutrition. A healthy diet is undoubtedly a major contributor for promoting a "good" microbial community that turns out to be crucial for a fine-tuned symbiotic relationship with the host. Both microbial-derived components and produced metabolites elicit...
Metabolically healthy obesity - heterogeneity in definitions and unconventional...
Brandão, Inês; Martins, Maria João; Monteiro, RosárioThe concept of heterogeneity among obese individuals in their risk for developing metabolic dysfunction and associated complications has been recognized for decades. At the origin of the heterogeneity idea is the acknowledgement that individuals with central obesity are more prone to developing type 2 diabetes and cardiovascular disease than those with peripheral obesity. There have been attempts to categorize ...
POPs’ effect on cardiometabolic and inflammatory profile in a sample of women w...
Ferro, Ana; Teixeira, Diana; Pestana, Diogo; Monteiro, Rosário; Santos, Cristina C.; Domingues, Valentina F.; Polónia, Jorge; Calhau, ConceiçãoPersistent organic pollutants (POPs) are man-made compounds with metabolic disruption impact. We investigated the effect of POP exposure in the cardiometabolic and inflammatory profile in a population of women with obesity and hypertension. In 43 premenopausal women (22 treated vs. 21 nontreated) undergoing bariatric surgery, blood and adipose tissue samples (visceral (vAT) and abdominal subcutaneous (scAT)) we...
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesi...
Pestana, Diogo; Teixeira, Diana; Meireles, Manuela; Marques, Cláudia; Norberto, Sónia; Sá, Carla; Fernandes, Virgínia; Correia-Sá, Luísa; Faria, AnaEndocrine-disrupting chemicals such as p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), are bioaccumulated in the adipose tissue (AT) and have been implicated in the obesity and diabetes epidemic. Thus, it is hypothesized that p,p'-DDE exposure could aggravate the harm of an obesogenic context. We explored the effects of 12 weeks exposure in male Wistar rats' metabolism and AT biology, assessing a range of met...
Inflammatory and Cardiometabolic Risk on Obesity: Role of Environmental Xenoest...
Teixeira, Diana; Pestana, Diogo; Santos, Cristina; Correia-Sá, Luísa; Marques, Cláudia; Norberto, Sónia; Meireles, Manuela; Faria, Ana; Silva, RicardoContext: Some chemicals used in consumer products or manufacturing (eg, plastics, pesticides) have estrogenic activities; these xenoestrogens (XEs) may affect immune responses and have recently emerged as a new risk factors for obesity and cardiovascular disease. However, the extent and impact on health of chronic exposure of the general population to XEs are still unknown. Objective: The objective of the study...
Inflammatory and Cardiometabolic Risk on Obesity: Role of Environmental Xenoest...
Teixeira, Diana; Pestana, Diogo; Santos, Cristina; Correia-Sá, Luísa; Marques, Cláudia; Norberto, Sónia; Meireles, Manuela; Faria, Ana; Silva, RicardoSome chemicals used in consumer products or manufacturing (eg, plastics, pesticides) have estrogenic activities; these xenoestrogens (XEs) may affect immune responses and have recently emerged as a new risk factors for obesity and cardiovascular disease. However, the extent and impact on health of chronic exposure of the general population to XEs are still unknown.