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Writing 3D In vitro models of human tendon within a biomimetic fibrillar suppor...
Monteiro, Rosa F.; Bakht, Syeda Mahwish; Gómez-Florit, Manuel; Stievani, Fernanda C.; Alves, Ana L. G.; Reis, R. L.; Gomes, Manuela E.Tendinopathies are poorly understood diseases for which treatment remains challenging. Relevant in vitro models to study human tendon physiology and pathophysiology are therefore highly needed. Here we propose the automated 3D writing of tendon microphysiological systems (MPSs) embedded in a biomimetic fibrillar support platform based on cellulose nanocrystals (CNCs) self-assembly. Tendon decellularized extra...
A dive into the bath: embedded 3D bioprinting of freeform in vitro models
Öztuerk-Öncel, M. Ö.; Leal-Martínez, Baltazar Hiram; Monteiro, Rosa F.; Gomes, Manuela E.; Domingues, Rui Miguel AndradeDesigning functional, vascularized, human scale in vitro models with biomimetic architectures and multiple cell types is a highly promising strategy for both a better understanding of natural tissue/organ development stages to inspire regenerative medicine, and to test novel therapeutics on personalized microphysiological systems. Extrusion-based 3D bioprinting is an effective biofabrication technology to engin...