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Aspartic acid unveils as antibiofilm agent and tobramycin adjuvant against muco...
Monteiro, Rosana Isabel Araújo; Sousa, Ana Margarida; Pereira, Maria OlíviaAntibiotics are central to managing airway infections in cystic fibrosis (CF), yet current treatments often fail due to the presence of Pseudomonas aeruginosa biofilms, settling down the need for seeking therapies targeting biofilms. This study aimed to investigate the antibiofilm activity of aspartic acid and its potential as an adjuvant to tobramycin against P. aeruginosa biofilms formed by mucoid and small c...
Investigating drug-loaded nanocarriers to treat Pseudomonas aeruginosa pulmonar...
Monteiro, Rosana Isabel AraújoP. aeruginosa é responsável pela elevada mortalidade e pelo estabelecimento de infeções crónicas em doentes com fibrose quística (FQ), principalmente devido à formação de biofilme. Várias abordagens terapêuticas, incluindo a combinação de antibióticos, têm sido utilizadas para tentar erradicar P. aeruginosa, no entanto, estas frequentemente falham. Dada a ineficácia dos antibióticos, tornou-se urgente desenvolv...
Mechanistic insights into succinic acid as an adjuvant for ciprofloxacin in tre...
Monteiro, Rosana Isabel Araújo; Silva, Eduarda; Pereira, Maria Olívia; Sousa, Ana MargaridaPseudomonas aeruginosa is a major cause of chronic respiratory infections in patients with cystic fibrosis (CF), with biofilm formation contributing to its persistence and antibiotic resistance. This study aimed to gain insights into the mechanistic action of succinic acid as a ciprofloxacin adjuvant against clinically relevant CF isolates, including small colony variants and mucoid strains, and a ciprofloxacin...
P. aeruginosa adaptation in cystic fibrosis environment challenged by the prese...
Monteiro, Rosana Isabel AraújoCystic fibrosis (CF) is a recessive genetic disease caused by mutations in the cystic fibrosis transmembrane regulator resulting in thick mucus that difficults proper airflow. CF airways are infected by several opportunistic pathogens but P. aeruginosa is the major responsible for the high mortality rate due to the development of chronic infections. To long persist, P. aeruginosa uses sophisticated mechanisms t...