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Exposure to Obesogenic Environments during Perinatal Development Modulates Offs...
Sousa, Diana; Sá-Rocha, Mariana; Amaro, Andreia; Ferreira-Junior, Marcos Divino; Cavalcante, Keilah Valéria Naves; Monteiro-Alfredo, TamaehObesogenic environments such as Westernized diets, overnutrition, and exposure to glycation during gestation and lactation can alter peripheral neuroendocrine factors in offspring, predisposing for metabolic diseases in adulthood. Thus, we hypothesized that exposure to obesogenic environments during the perinatal period reprograms offspring energy balance mechanisms. Four rat obesogenic models were studied: mat...
Acrocomia aculeata associated with doxorubicin: cardioprotection and anticancer...
Monteiro-Alfredo, Tamaeh; Dos Santos, Jéssica Maurino; Antunes, Kátia Ávila; Cunha, Janielle; da Silva Baldivia, Debora; Pires, Ana SaloméDoxorubicin (Dox) is a chemotherapeutic agent widely used in the clinic, whose side effects include cardiotoxicity, associated with decreased antioxidant defenses and increased oxidative stress. The association of Dox with natural antioxidants can extend its use if not interfering with its pharmacological potential. In this study, we aimed to understand the effects and mechanisms of the aqueous extract of Acroc...
Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-l...
Amaro, Andreia; Sousa, Diana Isabel Teixeira de; Sá-Rocha, Mariana; Ferreira-Junior, Marcos Divino; Rosendo-Silva, DanielaNutritional disturbances during the early postnatal period can have long-lasting effects on neurodevelopment and may be related to behavioural changes at adulthood. While such neuronal connection disruption can contribute to social and behaviour alterations, the dysregulation of the neuroendocrine pathways involved in nutrient-sensing balance may also cause such impairments, although the underlying mechanisms a...
Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex ...
Monteiro-Alfredo, Tamaeh; Oliveira, Sara; Amaro, Andreia; Rosendo-Silva, Daniela; Antunes, Katia; Pires, Ana Salomé dos SantosOxidative stress is involved in the metabolic dysregulation of type 2 diabetes (DM2). Acrocomia aculeata (Aa) fruit pulp has been described for the treatment of several diseases, and recently we have proved that its leaves have phenolic compounds with a marked antioxidant effect. We aimed to assess whether they can improve metabolic, redox and vascular functions in DM2. Control Wistar (W-Ctrl) and non-obese typ...
Distinct Impact of Natural Sugars from Fruit Juices and Added Sugars on Caloric...
Monteiro-Alfredo, Tamaeh; Caramelo, Beatriz; Arbeláez, Daniela; Amaro, Andreia; Barra, Cátia; Silva, Daniela; Oliveira, Sara; Seiça, RaquelAlthough fruit juices are a natural source of sugars, there is a controversy whether their sugar content has similar harmful effects as beverages' added-sugars. We aimed to study the role of fruit juice sugars in inducing overweight, hyperglycaemia, glycation and oxidative stress in normal and diabetic animal models. In diabetic Goto-Kakizaki (GK) rats, we compared the effects of four different fruit juices (4-...
Acrocomia aculeata (Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Impr...
Monteiro-Alfredo, Tamaeh; Matafome, Paulo N.; Iacia, Bianca Pancoti; Antunes, Kátia Ávila; Dos Santos, Jéssica Maurino; da Silva Melo da Cunha, JanielleOxidative stress is a metabolic disorder linked with several chronic diseases, and this condition can be improved by natural antioxidants. The fruit pulp of the palm Acrocomia aculeata (Jacq.) Lodd. ex Mart. is widely used in the treatment of various illnesses, but as far as we know, there are no reports regarding the properties of its leaves. Thus, we aimed to evaluate the antioxidant activity of A. aculeata l...