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Microglial depletion has no impact on disease progression in a mouse model of m...
Campos, Ana Bela; Silva, Sara Carina Duarte; Fernandes, Bruno; Coimbra, Bárbara; Campos, Jonas; Monteiro-Fernandes, Daniela; Teixeira-Castro, AndreiaMachado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is an autosomal dominant neurodegenerative disorder (ND). While most research in NDs has been following a neuron-centric point of view, microglia are now recognized as crucial in the brain. Previous work revealed alterations that point to an increased activation state of microglia in the brain of CMVMJD135 mice, a MJD mouse model ...
Date: 2022
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Origin: RepositóriUM - Universidade do Minho