188 documents found, page 1 of 19

Merkel Cell Carcinoma - A clinical case report

Aim: To report a case of Merkel cell carcinoma in a patient who presented with a rapidly growing cervical mass. Background: Merkel cell carcinoma is a rare and aggressive cutaneous malignant tumor, with a high recurrence rate and propensity for metastasis. Our goal is to alert and raise awareness among otorhinolaryngologists about this entity, especially in the differential diagnosis of neck masses. Case descri...

Games! What are they good for? : the struggle of serious game adoption for reha...

The field of serious games for health has grown significantly, demonstrating effectiveness in various clinical contexts such as stroke, spinal cord injury, and degenerative neurological diseases. Despite their potential benefits, therapists face barriers to adopting serious games in rehabilitation, including limited training and game literacy, concerns about cost and equipment availability, and a lack of eviden...

Counseling and Prescription of Physical Exercise in Medical Consultations in Po...

Abstract: Background/Objectives: Physical exercise (PE) is essential in promoting health and quality of life and protecting against chronic diseases. Health professionals are identified as key figures in promoting and prescribing PE, yet various factors may impact this during consultations. This study aims to assess Portuguese specialist physicians’ understanding of the importance of PE prescriptions. It will a...

EEG signatures during pregnancy and their role on parenting-related measures: s...

This scoping review aims to map and synthesise the current research evidence targeting the electroencephalography (EEG) neural correlates during pregnancy and its association with parenting-related measures during pregnancy and postpartum period. Pregnancy is characterised by a wide range of biological changes associated with adaptation to parenthood. A growing body of literature has examined the neural correla...

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The Use of New Therapies for Metastatic Castrate Resistant Prostate Cancer in t...

Introduction:New drugs such as abiraterone (Abi), enzalutamide (Enz), cabazitaxel (Cab) and radium 223 (Rad) were recently approved for metastatic castrate resistant prostate cancer (mCRPC) patients. However, their use in clinical practice is largely unknown, so the objective of this research is to describe their use in mCRPC patients in public hospitals in the north of Portugal. Methods:All mCRPC patients trea...

Medically Actionable Secondary Findings from Whole-Exome Sequencing (WES) Data ...

The application of whole-exome sequencing (WES) for diagnostic purposes has the potential to unravel secondary findings unrelated with the primary reason of testing. Some of those might be of high clinical utility and comprise disease-causing variants in genes, related to life-threatening and clinically actionable diseases. Clarifying the allelic frequencies of such variants in specific populations is a crucial...

Functional Characterization of ACAD9 Variants of Uncertain Significance Using a...

Background: ACAD9 is a mitochondrial protein involved in fatty acid β-oxidation and complex I assembly. Mutations in ACAD9 are associated with mitochondrial diseases (MD) of variable severity. Zebrafish (Danio rerio), with conserved mitochondrial physiology and genetic similarity to humans, is a valuable model for assessing the functional impact of variants of uncertain significance (VUS) in MD-related genes.

Exploring a novel approach to cybersecurity : the role of ecological simulation...

In response to the growing cybersecurity problem, this study presents an innovative approach using virtual reality to train individuals in reducing the risk of cyberattacks. The research involved 70 adult participants with or enrolled in higher education studies, who participated in a virtual reality task that simulates a typical workday in a corporate setting. The participants were divided into three groups: a...

Dos territórios megalíticos ao tratado de Alcanices na falda norte da Serra de ...

Neste capítulo tenta-se compreender a dinâmica da ocupação do território a norte da Serra de S. Mamede desde o Neolítico até à fronteira demarcada pelo Tratado de Alcanices.