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Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Misso...
Moosecker, Susanne; Gomes, Patrícia; Dioli, Chrysoula; Yu, Shuang; Sotiropoulos, I.; Almeida, Osborne F. X.Type 2 diabetes increases the risk for dementia, including Alzheimer's disease (AD). Pioglitazone (Pio), a pharmacological agonist of the peroxisome proliferator-activated receptor γ (PPARγ), improves insulin sensitivity and has been suggested to have potential in the management of AD symptoms, albeit through mostly unknown mechanisms. We here investigated the potential of Pio to counter synaptic malfunction an...
Data: 2019
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Origem: RepositóriUM - Universidade do Minho