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Bringing hope to improve treatment in pancreatic ductal adenocarcinoma - a new ...

Bravo, Ana Catarina; Morão, Bárbara; Luz, André; Dourado, Rúben; Oliveira, Beatriz; Guedes, Ana; Moreira-Barbosa, Catarina; Fidalgo, Catarina

Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC) incidence is rising, and prognosis remains poor due to late diagnosis and limited effective therapies. Currently, patients are treated based on TNM staging, without molecular tumor characterization. This study aimed to validate a technique that combines the amplification refractory mutation system (ARMS) with high-resolution melting analysis (HRMA) ...


COVID-19 Vaccination in Liver Cirrhosis: Safety and Immune and Clinical Responses.

Canha, Inês; Silva, Mário Jorge; Silva, Maria Azevedo; Sarmento Costa, Mara; Saraiva, Rita Ornelas; Ruge, André; Machado, Mariana Verdelho

Introduction: Three years after the beginning of the SARS-CoV-2 pandemic, the safety and efficacy of COVID-19 vaccination in liver cirrhosis (LC) patients remain controversial. We aimed to study the safety, immunological, and clinical responses of LC patients to COVID-19 vaccination. Methods: Prospective multicentric study in adults with LC eligible for COVID-19 vaccination, without prior known infection. Patie...


Inflammatory Bowel Disease patients’ perspectives during COVID-19 pandemic: res...

Revés, Joana Branco; Frias-Gomes, Catarina; Morão, Bárbara; Nascimento, Catarina; Palmela, Carolina; Fidalgo, Catarina; Roque Ramos, Lídia; Sampaio, Ana

Introduction: Patients with inflammatory bowel disease (IBD) do not seem to be at increased risk of infection by SARS-CoV-2, but there is a concern whether immunosuppressive therapy may be associated with more severe disease. Several clinical practice recommendations have been published to help guide IBD care during the COVID-19 pandemic. Nonetheless, few studies have addressed patients' perspectives and fears....


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