3 documents found, page 1 of 1
The onset of tacrolimus biosynthesis in streptomyces tsukubaensis is dependent ...
Pires, SDS; Oliveira, R; Moradas-Ferreira, P; Mendes, MVThe oxidative stress response is a key mechanism that microorganisms have to adapt to changeling environmental conditions. Adaptation is achieved by a fine-tuned molecular response that extends its influence to primary and secondary metabolism. In the past, the role of the intracellular redox status in the biosynthesis of tacrolimus in Streptomyces tsukubaensis has been briefly acknowledged. Here, we investigat...
The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation
Martins, TS; Pereira, C; Canadell, D; Vilaça, R; Teixeira, V; Moradas-Ferreira, P; Nadal, E; Posas, F; Costa, VIron acquisition systems have to be tightly regulated to assure a continuous supply of iron, since it is essential for survival, but simultaneously to prevent iron overload that is toxic to the cells. In budding yeast, the low‑iron sensing transcription factor Aft1p is a master regulator of the iron regulon. Our previous work revealed that bioactive sphingolipids modulate iron homeostasis as yeast cells lacking...
Streptomyces natalensis programmed cell death and morphological differentiation...
Beites, T; Oliveira, P; Rioseras, B; Pires, SD; Oliveira, R; Tamagnini, P; Moradas-Ferreira, P; Manteca, Á; Mendes, MVStreptomyces are aerobic Gram-positive bacteria characterized by a complex life cycle that includes hyphae differentiation and spore formation. Morphological differentiation is triggered by stressful conditions and takes place in a pro-oxidant environment, which sets the basis for an involvement of the oxidative stress response in this cellular process. Characterization of the phenotypic traits of Streptomycesn...