8 documents found, page 1 of 1
Atividade biológica de extratos orgânicos e aquosos de macroalgas marinhas do E...
Torres, Márcia Rocha; Sousa, Alessandra de Paula Alves; Silva Filho, Eduardo Augusto Torres da; Pessoa, Cláudia; Moraes, Maria Elisabete Amaral deThe present study evaluated the biological activity of 12 marine macroalgae from Ceará State, Brazil. From the collected species 48 extracts (aqueous, dichloromethane, acetone and methanol extracts for each species) were obtained. The activity of extracts were rated at the following bioactivities: lethality in brine shrimp nauplii, inhibition of the development of sea urchin eggs, hemolytic activity on mice ery...
Behavioral effects induced by antitumor cleronade diterpenes from Casearia sylv...
Ferreira de Araujo, Everton Jose; Cardoso de Almeida, Antonia Amanda; Silva, Oskar Almeida; Fernandes da Costa, Iwyson HenriqueMade available in DSpace on 2018-11-26T17:21:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-02-23; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundacao de Amparo a Pesquisa do Estado do Piaui [FAPEPI]; Ethnopharmacological relevance: Casearia sylvestris is a medicinal plant traditionally used to treat snakebites, wounds, inflammation and gastric ulcers and scientific support...
Preclinical anticancer effectiveness of a fraction from Casearia sylvestris and...
Pinheiro Ferreira, Paulo Michel; Bezerra, Daniel Pereira; Silva, Jurandy do Nascimento; Costa, Marcilia Pinheiro da; Oliveira Ferreira, Jose Roberto deMade available in DSpace on 2018-11-27T16:55:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-06-20; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Ethnopharmacological relevance: Casearia sylvestris (Salicaceae) is found in South America and presents antiulcerogenic, cytotoxic, antimicrobial, anti-inflammatory and antihypertensive activities. Aim of the study: To assess the in v...
Toxicology and safety of the tincture of Operculina alata in patients with func...
Santos, Luciana Kelly Ximenes dos; Cunha, Gilmara Holanda da; Fechine, Francisco Vagnaldo; Pontes, Andréa Vieira; Oliveira, Jonaina Costa deThe tincture of Operculina alata, popularly known as "tincture of jalapa", is used in Northeast Brazil to treat constipation and encephalic vascular accident, but it has not yet been adequately tested for safety and efficacy. The aim of this study was to evaluate the toxicology and safety of the tincture of O. alata in patients with functional constipation. This was a double-blind, randomized, placebo-controlle...
In vitro cytotoxic activity of Brazilian Middle West plant extracts
Mahmoud, Talal Suleiman; Marques, Maria Rita; Pessoa, Cláudia do Ó; Lotufo, Leticia Veras Costa; Magalhães, Hemerson Iury FerreiraABSTRACT - Cytotoxic activity of eight plant extracts, native from the Mid-West of Brazil comprising Cerrado, Pantanal and semideciduous forest, was evaluated for MDA-MB-435, SF-295, and HCT-8 cancer cell strains. A single 100 µg.mL-1 dose of each extract was employed with 72 h of incubation for all tests. Doxorubicin (1 µg.mL-1) was used as the positive control and the MTT method was used to detect the activit...
Synthesis and biological evaluation of new salicylate macrolactones from anacar...
Logrado, Lucio Paulo Lima; Silveira, Dâmaris; Romeiro, Luiz Antonio Soares; Moraes, Manoel Odorico de; Cavalcanti, Bruno CôelhoNo âmbito de uma linha de pesquisa que visa a obtenção de novas substâncias bioativas, a partir de lipídeos fenólicos não-isoprenóides de Anacardium occidentale, descrevemos a síntese e avaliação citotóxica de novas macrolactonas salicílicas, preparadas a partir da mistura de ácidos anacárdicos, principal constituinte do líquido da casca da castanha de caju (LCC) in natura.; In connection with our ongoing inves...
Constituintes químicos de Parmotrema lichexanthonicum Eliasaro & Adler - isolam...
Micheletti, Ana Carolina; Beatriz, Adilson; Lima, Dênis Pires de; Honda, Neli Kika; Pessoa, Cláudia do Ó; Moraes, Manoel Odorico deFrom the lichen Parmotrema lichexantonicum were isolated the depsidone salazinic acid, the xanthone lichexanthone, and the depside atranorin. The two major compounds, salazinic acid and lichexanthone, were selected for structure modifications. Salazinic acid afforded O-alkyl salazinic acids, some of them potentially cytotoxic against tumor cell lines (HCT-8, SF-295 and MDA/ MB - 435). From lichexanthone were ob...
Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic applica...
Nascimento, Demétrius Fernandes do; Moraes, Manoel Odorico de; Bezerra, Fernando Antônio Frota; Pontes, Andréa Vieira; Uchoa, Célia Regina AmaralTo develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic separation was performed on a Varian® Polaris C18 analytical column (3 μm, 50 x 2.0 mm) and pre-column Securitygu...