23 documents found, page 1 of 3
Kinase inhibition in relapsed/refractory leukemia and lymphoma settings: recent...
Machado, Caio Bezerra; Pessoa, Flávia Melo Cunha de Pinho; Silva, Emerson Lucena da; Pantoja, Laudreísa da Costa; Ribeiro, Rodrigo MonteiroCancer is still a major barrier to life expectancy increase worldwide, and hematologic neoplasms represent a relevant percentage of cancer incidence rates. Tumor dependence of continuous proliferative signals mediated through protein kinases overexpression instigated increased strategies of kinase inhibition in the oncologic practice over the last couple decades, and in this review, we focused our discussion on...
Identificação de alterações genéticas e sua influência prognóstica na Leucemia ...
Santos, Nagyla Brenna Gonçalves dos; Nogueira, Beatriz Maria Dias; Sousa, Isabelle Cerqueira; Moraes, Maria Elisabete Amaral de“Brasil” entre os anos 2009 a 2019. Os resultados indicam que a presença da alteração na expressão dos genes HDAC3, HDAC7, HADC9 e TIMP1 estão associados a taxa de sobrevida > 5 anos. Um alelo variante do gene IKZF1 conferiu maior risco de desenvolvimento de LLA-B. A baixa expressão do gene ABCG2 foi associado ao pior prognóstico e está relacionada a resposta a quimioterapia. Crianças com hiperdiploidia tem mai...
Atividade biológica de extratos orgânicos e aquosos de macroalgas marinhas do E...
Torres, Márcia Rocha; Sousa, Alessandra de Paula Alves; Silva Filho, Eduardo Augusto Torres da; Pessoa, Cláudia; Moraes, Maria Elisabete Amaral deThe present study evaluated the biological activity of 12 marine macroalgae from Ceará State, Brazil. From the collected species 48 extracts (aqueous, dichloromethane, acetone and methanol extracts for each species) were obtained. The activity of extracts were rated at the following bioactivities: lethality in brine shrimp nauplii, inhibition of the development of sea urchin eggs, hemolytic activity on mice ery...
The influence of agrochemicals present in maternal nutrition in the birth of ch...
Carneiro, Carla Larissa de Castro Vieira; Oliveira, Nayrene Amorin Carvalho de; Bachur, Tatiana Paschoalette RodriguesBoth psychological and neurological changes are related to deficits in communication and social interaction in patients diagnosed with autism spectrum disorder (ASD). There is evidence that fetuses are exposed to agrochemicals because some agrochemicals have the capacity to cross the blood-brain barrier, thus affecting the fetal central nervous system. The aim of the present study is to carry out a literature r...
Análise in silico da farmacocinética e farmacodinâmica do composto benzotiazóli...
Mesquita, Felipe Pantoja; Lima, Luina Benevides; Daniel, Julio Paulino; Portilho, Adrhyann Jullyanne de Sousa; Oliveira, Lais Lacerda Brasil deGastric adenocarcinoma has high incidence and mortality rates worldwide. The aim of this study was to evaluate the antitumor activity of benzothiazole AFN01 against ACP03 gastric adenocarcinoma cell line. Furthermore, computational prediction of the pharmacokinetics and pharmacodynamics of this molecule and the molecular docking with the relevant pharmacological target found were performed. The MTT assay was pe...
O uso de linhagens leucêmicas e a sua importância na oncologia experimental
Sales, Lívia de Oliveira; Nogueira, Beatriz Maria Dias; Silva, Emerson Lucena da; Moraes, Maria Elisabete Amaral de; Montenegro, Raquel CarvalhoExperimental oncology is based on a model of study through cell culture, a technique frequently used for the study of cancer biology and for tests of new anticancer therapies. This model provides an appropriate system for researching the effects of drugs and toxic compounds on cells, mutagenesis and carcinogenesis, in drug screening and development. In addition the cell lines allows consistent and reproducible ...
Leu124Serfs*26, a novel AGPAT2 mutation in congenital generalized lipodystrophy...
Montenegro Junior, Renan Magalhães; Lima, Grayce Ellen da Cruz Paiva; Fernandes, Virgínia Oliveira; Montenegro, Ana Paula Dias RangelBackground: Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by the near-total loss of subcutaneous adipose tissue soon after birth, resulting in ectopic fat deposition and severe metabolic disturbances. Most cases are caused by AGPAT2 or BSCL2 gene mutations. We aimed to report two unrelated CGL patients with a novel frameshift mutation in AGPAT2 (p.Leu124Serfs*26...
Evidence for host epigenetic signatures arising from arbovirus infections: a sy...
Aguiar, Gabriella Pequeno Costa Gomes de; Leite, Claudio Manuel Gonçalves da Silva; Dias, Beatriz; Vasconcelos, Silvania Maria MendesBackground: Arbovirus infections have steadily become a major pandemic threat. This study aimed at investigating the existence of host epigenetic markers arising from the principal arboviruses infections impacting on human health. We set to systematically review all published evidence describing any epigenetic modifications associated with infections from arboviruses, including, but not limited to, microRNAs, D...
Innovative treatment using tilapia skin as a xenograftfor partial thickness bur...
Lima-Junior, Edmar Maciel; Moraes Filho, Manoel Odorico de; Costa, Bruno Almeida; Fechine, Francisco Vagnaldo; Moraes, Maria Elisabete Amaral deTilapia skin has non-infectious microbiota, high amounts of type I collagen, and similar morphological structure to human skin, so it has been suggested as a potential xenograft for the management of burn wounds. A 23-year-old male patient, with no comorbidities, arrived at our burn treatment center after a thermal injury caused by contact with flames from a gunpowder explosion. Superficial partial thickness bu...
Clinical trial for uniform multidrug therapy for leprosy patients in Brazil (U-...
Cruz, Rossilene Conceição da Silva; Bührer-Sékula, Samira; Penna, Gerson Oliveira; Moraes, Maria Elisabete Amaral de; Gonçalves, Heitor de SáBACKGROUND: The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR), designed to evaluate the effectiveness of a six-months regimen, assessed the adverse effects caused by the drugs. OBJECTIVE: Describe adverse effects due to MDT in U-MDT/CT-BR, comparing the uniform regimen (U-MDT) to the current WHO regimen (R-MDT). Patients and methods: After operational classification, ...