19 documents found, page 1 of 2
Impact of testicular sperm extraction and testicular sperm aspiration on gonada...
Barroso,Leocácio Venícius Sousa; Reges,Ricardo; Cerqueira,João Batista Gadelha; Miranda,Eduardo P.; Alcantara,Rafael Jorge Alves deABSTRACT Purpose To assess the impact of sperm retrieval on the gonadal function of rats with impaired spermatogenesis by comparing testicular sperm extraction (TESE) to aspiration (TESA). The efficacy of these procedures to sperm obtainment was also compared. Materials and Methods A pilot study showed impaired spermatogenesis, but normal testosterone (T) production after a bilateral orchidopexy applied to 26 r...
Potential chemoprotective effects of green propolis, L-lysine and celecoxib on ...
Dornelas,Conceição Aparecida; Cavalcanti,Bruno Coelho; Magalhães,Hemerson Iury Ferreira; Jamacaru,Francisco Vagnaldo FechinePURPOSE:To evaluate the genotoxicity of propolis and L-lysine, as well as their effects on the possible cellular damage in erythroblasts (bone marrow) and leukocytes (peripheral blood) caused by the carcinogen BBN (n - butyl - n {4 - hydroxybutyl} nitrosamine) in rats subjected to bladder carcinogenesis and treated with green propolis and L-lysine.METHODS: One hundred and twenty five rats were distributed into ...
Effects of chronic administration of tamsulosin and tadalafil, alone or in comb...
Regadas,Rommel Prata; Reges,Ricardo; Cerqueira,João Batista Gadelha; Sucupira,Daniel Gabrielle; Jamacaru,Francisco Vagnaldo F.; Moraes,Manoel Odorico dePurpose The aim of this study was to define if tadalafil causes detrusor muscle impairment and to observe the effect of combination of tadalafil with tamsulosin on the lower urinary tract of rats with bladder outlet obstruction (BOO) induced by chronic nitric oxide deficiency. Materials and Methods Thirty-one male rats were randomized to following groups: 1 - control; 2 - L-Nitroarginine methyl ester (L-NAME); ...
Perfil de flavonoides e avaliação do potencial antioxidante e citotóxico de Bau...
Santos,Priscila Moraes dos; Almeida,Patrícia Danielle Oliveira de; Lima,Emerson Silva; Moraes,Manoel Odorico de; Costa,Patrícia Marçal daBauhinia purpurea (Fabaceae). Plants of the Bauhinia species (Fabaceae) are used in the treatment of several infections and diseases, especially diabetes. In this paper, with an aim to contribute to the knowledge of the chemistry and therapeutic potential of the Amazonian species of the genus Bauhinia, flavonoid profiles in the leaves and branches of Bauhinia purpurea collected in Manaus and São Gabriel da Cach...
Constituintes químicos das cascas do caule de Vochysia thyrsoidea Pohl. (Vochys...
Sousa,Lorena Ramos Freitas de; Silva,Jame's A. da; Vieira,Paulo Cezar; Costa,Maísa Borges; Santos,Mirley Luciene dos; Sbardelotto,Aline BorbaA new flavonoid, catechin-3-O-(3"-O-trans-cinnamoyl)-α-rhamnopyranoside, along with known compounds, catechin-3-O-α-rhamnopyranoside, 3-oxo-urs-12-en-28-oic acid, 2,4,6-trimethoxybenzoic acid, 2-butyl-D-fructofuranoside and 1-butyl-D-fructofuranoside, has been isolated from the stem bark of V. thyrsoidea. These compounds were assayed for inhibition of protease activity (cathepsins B and K) and against cancer ce...
Susceptibility to amphotericin B of Candida spp. strains isolated in Ceará, Nor...
Silva,Cecília Rocha da; Magalhães,Hemerson Iury Ferreira; Moraes,Manoel Odorico de; Nobre Júnior,Hélio VitorianoIntroductionAmphotericin B (AMB) is an antifungal agent used extensively in clinical medicine, yet resistance remains low. This study aims to evaluate the susceptibility of Candida spp. against AMB.MethodsFor broth microdilution susceptibility testing, 77 strains of Candida spp. were selected (32 C. albicans, 33 C. tropicalis, and 12 C. parapsilosis). The strains were considered susceptible when they exhibited ...
Trachylobane and kaurane diterpenes from Croton floribundus spreng
Uchôa,Paula Karina S.; Silva Jr.,José Nunes da; Silveira,Edilberto Rocha; Lima,Mary Anne S.; Braz-Filho,Raimundo; Costa-Lotufo,Letícia VerasA new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatizati...
Blainvillea rhomboidea: constituintes químicos e atividade citotóxica
Gomes,Regina Ferreira; Santos,Hélcio Silva dos; Albuquerque,Maria Rose Jane R.; Pessoa,Otília Deusdênia L.; Lotufo,Leticia V. Costa; Pessoa,Claudia do ÓThe phytochemical investigation of the ethanol extract from the aerial parts of Blainvillea rhomboidea (Asteraceae) resulted in the isolation and characterization of 8β-tigloyloxy-grazielia acid, together with the flavonoids derrone, acacetin, luteolin and luteolin 7-methyl ether, and p-(1-methyl-ethan-1-ol)-phenol. The structures of all compounds were determined by spectroscopic methods (¹H and 13C NMR and HRE...
Estudo de toxicologia clínica de um fitoterápico contendo Passiflora incarnata ...
Nascimento,Demétrius F.; Santana,Ana Paula M.; Leite,Ismenia O.; Viana,Fernando André C.; Leite,Ana Lourdes A. e Silva; Moraes,Renata A. deO Pasalix® é um produto fitoterápico contendo uma associação de três plantas medicinais: Passiflora incarnata, Salix alba e Crataegus oxyacantha. Sua principal indicação é para o tratamento da ansiedade e insônia. O objetivo desse estudo foi avaliar a toxicologia clínica dessa formulação em voluntários saudáveis. Para isso realizou-se um ensaio clínico não aleatório, aberto, com 24 voluntários sadios do sexo ma...
Cytotoxic, trypanocidal activities and physicochemical parameters of nor-²-lapa...
Silva Júnior,Eufrânio N. da; Moura,Maria Aline B. F. de; Pinto,Antonio V.; Pinto,Maria do Carmo F. R.; Souza,Maria Cecília B. V. de; Araújo,Ana J.The cytotoxicities of five nor-²-lapachone-based 1,2,3-triazoles and the precursor azidonaphthoquinone were assayed against six neoplasic cancer cell lines: SF-295 (central nervous system), HCT-8 (colon), MDAMB-435 (melanoma), HL-60 (leukaemia), PC-3 (prostate) and B-16 (murine melanoma). IC50 values ranging from 0.43 to 9.48 µM were obtained. 3-(4-(1-hydroxycyclohexyl)-1H-1,2,3-triazol-1yl)-2,2-dimethylnaphtho...