14 documents found, page 1 of 2
Clinical spectrum time course in non-Asian patients positive for anti-MDA5 anti...
Cavagna, Lorenzo; Meloni, Federica; Meyer, Alain; Sambataro, Gianluca; Belliato, Mirko; De Langhe, Ellen; Cavazzana, Ilaria; Pipitone, NicolòObjectives: To define the clinical spectrum time-course and prognosis of non-Asian patients positive for anti-MDA5 antibodies. Methods: We conducted a multicentre, international, retrospective cohort study. Results: 149 anti-MDA5 positive patients (median onset age 53 years, median disease duration 18 months), mainly females (100, 67%), were included. Dermatomyositis (64, 43%) and amyopathic dermatomyositis (47...
Biological Therapy in Patients with Rheumatoid Arthritis in a Tertiary Center i...
Fernandes, Melissa; Figueiredo, Adelaide; Oliveira, Ana Luísa; Ferreira, Ana Carolina; Mendonça, Pedro; Taulaigo, Anna V.; Vicente, MadalenaIntroduction: Clinical outcomes in rheumatoid arthritis have greatly improved with therapeutic advances. Despite the availability of substantial clinical trial evidence, there is a lack of real-life data. The aim of this study was to assess disease status and quality of life in an outpatient population treated with biological disease-modifying anti-rheumatic drugs.Material and Methods: Cross-sectional study rec...
Neurodegeneration in systemic lupus erythematosus: layer by layer retinal study...
Dias-Santos, Arnaldo; Tavares Ferreira, Joana; Pinheiro, Sofia; Cunha, João Paulo; Alves, Marta; Papoila, Ana L.; Moraes-Fontes, Maria FranciscaSystemic lupus erythematosus (SLE) is a chronic, autoimmune and multisystemic disease. Recent studies with functional and structural magnetic resonance imaging and cognitive tests report an unexpectedly high frequency of central nervous system involvement, even in patients with asymptomatic SLE. The purpose of this study was to identify early signs of retinal neurodegeneration by comparing the thickness of the ...
Choroidal thickness changes in systemic lupus erythematosus patients
Dias-Santos, Arnaldo; Tavares Ferreira, Joana; Pinheiro, Sofia; Cunha, João Paulo; Alves, Marta; Papoila, Ana Luísa; Moraes-Fontes, Maria FranciscaPurpose: To compare choroidal thickness (CT) between patients with systemic lupus erythematosus (SLE) without ophthalmologic manifestations and a control group. To study the effects in CT of disease duration, activity index, medication and systemic comorbidities. Methods: Cross-sectional study where spectral-domain optical coherence tomography with enhanced depth imaging was used to measure CT in 13 locations, ...
Undifferentiated connective tissue disease : state of the art on clinical pract...
Antunes, Margarida; Scirè, Carlo Alberto; Talarico, Rosaria; Alexander, Tobias; Avcin, Tadej; Belocchi, Chiara; Doria, Andrea; Franceschini, FrancoThe term 'undifferentiated connective tissue disease' (UCTD) is generally used to describe clinical entities characterised by clinical and serological manifestations of systemic autoimmune diseases but not fulfilling the criteria for defined connective tissue diseases (CTDs). In this narrative review, we summarise the results of a systematic literature research, which was performed as part of the ERN ReCONNET p...
Idiopathic inflammatory myopathies : state of the art on clinical practice guid...
Meyer, Alain; Scirè, Carlo Alberto; Talarico, Rosaria; Alexander, Tobias; Amoura, Zahir; Avcin, Tadej; Barsotti, Simone; Beretta, LorenzoIdiopathic inflammatory myopathies (IIMs) encompass a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and inflammation, but in antisynthetase syndrome arthritis and interstitial lung disease are more frequent and often inaugurate the disease. Clinical practice guidelines (CPGs) have been proposed for IIMs, but they are sparse and heterogeneous. This work aimed at identifying: i)...
Heterogeneous lupus‐specific lesions and treatment outcome, in a single patient...
Fernandes, Melissa; Taulaigo, Anna V.; Vidal, Carolina; Agostini, Patrick; Riso, Nuno; Moraes-Fontes, Maria FranciscaThe report highlights the importance of strict clinico-histological correlations when skin biopsies are performed in diagnostic doubt in systemic lupus erythematosus. Furthermore, PUVA is never indicated in autoimmune conditions involving photosensitivity, due to high potential for internal and cutaneous aggravation of the disease, as the authors observed in this case.
Clinical Presentation and Long-Term Outcomes of Systemic Sclerosis Portuguese P...
Vidal, Carolina; Ruano, Carina; Bernardino, Vera; Lavado Carreira, Pedro; Lladó, Ana; Santos, Maria Céu; Gruner, Heidi; Panarra, António; Riso, NunoIntroduction: Systemic sclerosis is a complex disorder that requires systematic screening. Our objective is to report the European Scleroderma Trials and Research group centre affiliation and its impact in our clinical practice.Material and Methods: The European Scleroderma Trials and Research group affiliation process, database update and current patient evaluation, with respect to demographic and clinical fea...
Errata a “Estudo Monocêntrico da Apresentação Clínica e Prognóstico a Longo Pra...
Vidal, Carolina; Ruano, Carina; Bernardino, Vera; Lavado Carreira, Pedro; Lladó, Ana; Santos, Maria Céu; Gruner, Heidi; Panarra, António; Riso, NunoArticle published with errors: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10658On page 312, where the authors’ line reads as:Carolina VIDAL1, Carina RUANO2, Vera BERNARDINO3, Pedro LAVADO CARREIRA3, Ana LLADÓ3, Maria Céu SANTOS4, Heidi GRUNER3, António PANARRA3, Nuno RISO3, Maria Francisca MORAES-FONTESAC,1It should read:Carolina VIDAL1,2, Carina RUANO3, Vera BERNARDINO1, Pedro LAVA...
Determinant Factors of Morbidity in Patients with Systemic Lupus Erythematosus
Jacinto, Margarida; Silva, Eliana; Riso, Nuno; Moraes-Fontes, Maria FranciscaIntroduction: Severity in systemic lupus erythematosus may vary from mild to even fatal consequences. There are no biomarkers to predict the disease’s prognosis. The Systemic Lupus International Collaborating Clinics/ Systemic Damage Index defines systemic lupus erythematosus disease severity and is found to predict prognosis.Objective: To test damage determinants in a single-centre systemic lupus erythematosus...