7 documents found, page 1 of 1
Functional recovery of injured cavernous nerves achieved through endogenous ner...
Casanova, Marta R.; Mota, Paulo; Vala, Helena; Nóbrega, Carmen; Morais, Alain da Silva; Silva, Catarina S.; Barros, Alexandre A.; Reis, R. L.Radical prostatectomy is a highly successful treatment for prostate cancer, among the most prevalent manifestations of the illness. Damage of the cavernous nerve (CN) during prostatectomy is the main cause of postoperative erectile dysfunction (ED). In this study, the capability of a personalized bioactive fibrous membrane to regenerate injured CN was investigated. The fibrous membrane bioactivity is conferred ...
Functional recovery of injured cavernous nerves achieved through endogenous ner...
Casanova, Marta R.; Mota, Paulo; Vala, Helena; Nóbrega, Carmen; Morais, Alain da Silva; Silva, Catarina S.; Barros, Alexandre A.; Reis, Rui L.Radical prostatectomy is a highly successful treatment for prostate cancer, among the most prevalent manifestations of the illness. Damage of the cavernous nerve (CN) during prostatectomy is the main cause of postoperative erectile dysfunction (ED). In this study, the capability of a personalized bioactive fibrous membrane to regenerate injured CN was investigated. The fibrous membrane bioactivity is conferred ...
Injectable laminin-biofunctionalized gellan gum hydrogels loaded with myoblasts...
Alheib, Omar; Silva, Lucília Pereira; Morais, Alain da Silva; Mesquita, Katia A.; Pirraco, Rogério P.; Reis, R. L.; Correlo, V. M.Moderate muscular injuries that exceed muscular tissue's auto-healing capacity are still a topic of noteworthy concern. Tissue engineering appeared as a promising therapeutic strategy capable of overcoming this unmet clinical need. To attain such goal, herein we propose an in situ-crosslinking gellan gum (GG)-based hydrogel tethered with a skeletal muscle-inspired laminin-derived peptide RKRLQVQLSIRTC(Q) and en...
Combinatory approach for developing silk fibroin scaffolds for cartilage regene...
Ribeiro, Viviana P.; Morais, Alain da Silva; Maia, F. Raquel; Canadas, R. F.; Costa, João B.; Oliveira, Ana L.; Oliveira, Joaquim M.; Reis, Rui L.Several processing technologies and engineering strategies have been combined to create scaffolds with superior performance for efficient tissue regeneration. Cartilage tissue is a good example of that, presenting limited self-healing capacity together with a high elasticity and load-bearing properties. In this work, novel porous silk fibroin (SF) scaffolds derived from horseradish peroxidase (HRP)-mediated cro...
Combinatory approach for developing silk fibroin-based scaffolds seeded with hu...
Ribeiro, Viviana; Morais, Alain da Silva; Maia, Fátima; Oliveira, Ana; Oliveira, Joaquim; Reis, RuiSeveral processing technologies have been combined to create scaffolds for different tissue engineering (TE) applications. Hydrogels have been extensively used for cartilage TE applications, presenting several structural similarities to the natural extracellular matrix of cartilage tissue environment[1]. From the different biodegradable materials proposed as matrices for cartilage scaffolding[2], silk fibroin (...
Silk-based anisotropical 3D biotextiles for bone regeneration
Ribeiro, Viviana P.; Silva-Correia, Joana; Nascimento, Ana I.; Morais, Alain da Silva; Marques, Alexandra P.; Ribeiro, Ana S.; Silva, Carla J.Bone loss in the craniofacial complex can been treated using several conventional therapeutic strategies that face many obstacles and limitations. In this work, novel three-dimensional (3D) biotextile architectures were developed as a possible strategy for flat bone regeneration applications. As a fully automated processing route, this strategy as potential to be easily industrialized. Silk fibroin (SF) yarns w...
Tumor growth suppression induced by biomimetic silk fibroin hydrogels
Yan, Le-Ping; Silva-Correia, Joana; Ribeiro, Viviana P.; Miranda-Gonçalves, Vera; Correia, Cristina; Morais, Alain da Silva; Sousa, Rui A.; Reis, Rui M.Protein-based hydrogels with distinct conformations which enable encapsulation or differentiation of cells are of great interest in 3D cancer research models. Conformational changes may cause macroscopic shifts in the hydrogels, allowing for its use as biosensors and drug carriers. In depth knowledge on how 3D conformational changes in proteins may affect cell fate and tumor formation is required. Thus, this st...