35 documents found, page 1 of 4

Decoding host-environment interactions in progressive pulmonary fibrosis: insig...

Interstitial lung diseases (ILDs) comprise a heterogeneous group of parenchymal lung disorders characterized by diffuse infiltration of immune effector cells, fibroblasts, myofibroblasts, and extracellular matrix deposition at various pulmonary compartments. These conditions can progress to end-stage fibrosis, respiratory failure, and eventually, death. In 2020, we initiated the first national ILD registry and ...

Unmasking the hidden threat: COPD awareness and knowledge in Portugal

The burden of Chronic Obstructive Pulmonary Disease (COPD) is recognised worldwide, constituting a major public health problem due to significant morbidity and mortality. Portugal is not an exception to the impact of the COPD burden. The most recent data for the Portuguese population indicates that COPD is the fifth cause of death, with an estimated prevalence of 14.2% for individuals > 40 years old, as shown i...

Unveiling common molecular pathways linked to ILDs with progressive fibrosing p...

Progressive fibrosing ILDs (PF-ILDs) comprise a heterogeneous group of lung disorders associated with high morbidity and mortality, that exhibit a continuous worsening phenotype despite standard treatment. Among PF-ILDs are pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (HP), involving complex interactions between host genetics and different environmental triggers, shaping the immune milieu ...

Comprehensive assessment of environmental fungus-reactive T cells response in h...

Hypersensitivity pneumonitis (HP) is an interstitial lung disease that results in parenchymal and small airways inflammation and culminates in breathlessness, negatively impacting patient’s quality of life and survival. HP is initiated by an exaggerated immune response triggered by the inhalation of a variety of environmental antigens. The identification of the triggering antigen is a cornerstone of the diagnos...

3DCP prefabrication for complex topographical contexts: a case study of rocky p...

This article explores the potential offered by 3D Concrete Printing (3DCP) through the analysis of a practical application case: the qualification of rocky pontoons in marginal areas with spaces for recreational use and protectors of marine biodiversity. The purpose of the work is centred on the production of a set of platforms, divided into prefabricated concrete modules, which fit perfectly into the complex g...

Strategies of Learning and control of robotic manufacturing methods in architec...

Over the last decade, robotics applied to the Architecture and Construction sector has evolved through the support of new programming tools. The possibility of controlling robotic arms through visual programming languages has emerged as an opportunity to program industrial robots effectively, taking advantage of their multiple capabilities. This type of control turns the use of robotics accessible to non-specia...

Do Variant Histologies of Urothelial Carcinoma change the survival outcome in p...

Active Learning “Factory of Boxes” in the Teaching-Learning Processes in Engine...

"Factory of Boxes” is an Active Learning (AL) where concepts related to Industrial Engineering, Mechanics, Mechatronics, Electrotechnics and Entrepreneurial Management can be cultivated. The interconnection of these concepts offers the possibility of developing occupational related skills in the most diverse areas of knowledge. It is the use of AL, simulating the method of a factory which produces cardboard box...

Reuse of ceramic roof tiles: enhancing new functional design possibilities thro...

The material qualities of ceramic roof tiles have provided new formal interpretations that induced a new functional use-a wall. By disassembling ceramic roof tiles from roofs and assembling them into walls, its circularity potential was enlarged. This paper explores the potential use of ceramic roof tiles, as a single element type, in the definition of wall design systems and patterns of composition that comply...

Produção de elipses e hipérboles na biografia cinematográfica

Na construção da biografia (vida escrita), a genealogia, frequentemente suportada por razões históricas e políticas, enquanto ciência, valoriza a investigação, para a produção de uma árvore híper-informativa, representando alegoricamente a família, com lacunas eventuais por carência de informação, no entanto, o texto literário, suportado pela apresentação icónica do real ou da ficção, valoriza para a biografia ...