43 documents found, page 1 of 5
Epidemiology and Burden of Ventilator-Associated Pneumonia among Adult Intensiv...
Mergulhão, P; Pereira, JG; Fernandes, AV; Krystopchuk, A; Ribeiro, J; Miranda, D; Castro, H; Eira, C; Morais, J; Lameirão, C; Gomes, S; Leal, DVentilator-associated pneumonia (VAP) is a prevailing nosocomial infection in critically ill patients requiring invasive mechanical ventilation (iMV). The impact of VAP is profound, adversely affecting patient outcomes and placing a significant burden on healthcare resources. This study assessed for the first time the contemporary VAP epidemiology in Portugal and its burden on the healthcare system and clinical...
Epidemiology and Burden of Ventilator-Associated Pneumonia among Adult Intensiv...
Mergulhão, P; Pereira, JG; Fernandes, AV; Krystopchuk, A; Ribeiro, JM; Miranda, D; Castro, H; Eira, C; Morais, J; Lameirão, C; Gomes, S; Leal, DVentilator-associated pneumonia (VAP) is a prevailing nosocomial infection in critically ill patients requiring invasive mechanical ventilation (iMV). The impact of VAP is profound, adversely affecting patient outcomes and placing a significant burden on healthcare resources. This study assessed for the first time the contemporary VAP epidemiology in Portugal and its burden on the healthcare system and clinical...
The Cardiometabolic Impact of Rebaudioside A Exposure during the Reproductive S...
Bracchi, I; Morais, J; Coelho, JA; Ferreira, AF; Alves, I; Mendes, C; Correia, B; Gonçalves, A; Guimarães, JT; Pires, IF; Keating, E; Negrão, RThe consumption of non-sugar sweeteners (NSS) has increased during pregnancy. The European Food Safety Agency suggested that steviol glycosides, such as Rebaudioside A (RebA), the major sweetener component of stevia, are safe for humans up to a dose of 4 mg/kg body weight/day. However, the World Health Organization recommended in 2023 the restraint of using NSS, including stevia, at any life stage, highlighting...
Changes in Microbiota Profile in the Proximal Remnant Intestine in Infants Unde...
Barreiros-Mota, I; R. Araújo, J; Marques, C; Sousa, L; Morais, J; Castela, I; Faria, A; Neto, MT; Cordeiro-Ferreira, G; Virella, D; Pita, AEarly-life gut dysbiosis has been associated with an increased risk of inflammatory, metabolic, and immune diseases later in life. Data on gut microbiota changes in infants undergoing intestinal surgery requiring enterostomy are scarce. This prospective cohort study examined the enterostomy effluent of 29 infants who underwent intestinal surgery due to congenital malformations of the gastrointestinal tract, nec...
Characterization and biofouling potential analysis of two cyanobacterial strain...
Romeu, MJ; Morais, J; Luciana Gomes; Silva, R; Vitor Vasconcelos; Filipe MergulhãoThis work assesses the isolation, identification and characterization of two cyanobacterial strains isolated from Morocco and Cape Verde, as well as their biofilm-forming ability at two different surfaces, in a long-term assay under controlled hydrodynamic conditions. Cyanobacteria are new sources of value-added compounds but also ubiquitous and harmful microfoulers on marine biofouling. In this work, the isola...
Effect of Hydrogen Peroxide on Cyanobacterial Biofilms
Romeu, MJ; Morais, J; Vitor Vasconcelos; Filipe MergulhãoAlthough a range of disinfecting formulations is commercially available, hydrogen peroxide is one of the safest chemical agents used for disinfection in aquatic environments. However, its effect on cyanobacterial biofilms is poorly investigated. In this work, biofilm formation by two filamentous cyanobacterial strains was evaluated over seven weeks on two surfaces commonly used in marine environments: glass and...
How do Graphene Composite Surfaces Affect the Development and Structure of Mari...
Maria João Romeu; Luciana Gomes; Sousa Cardoso, F; Morais, J; Vitor Vasconcelos; Whitehead, KA; Pereira, MFR; Soares, OSGP; Filipe MergulhãoThe progress of nanotechnology has prompted the development of novel marine antifouling coatings. In this study, the influence of a pristine graphene nanoplatelet (GNP)-modified surface in cyanobacterial biofilm formation was evaluated over a long-term assay using an in vitro platform which mimics the hydrodynamic conditions that prevail in real marine environments. Surface characterization by Optical Profilome...
The Use of 3D Optical Coherence Tomography to Analyze the Architecture of Cyano...
Maria João Romeu; Lima, M; Luciana Gomes; de Jong, ED; Morais, J; Vitor Vasconcelos; Pereira, MFR; Soares, OSGP; Sjollema, J; Filipe MergulhãoThe development of environmentally friendly antifouling strategies for marine applications is of paramount importance, and the fabrication of innovative nanocomposite coatings is a promising approach. Moreover, since Optical Coherence Tomography (OCT) is a powerful imaging technique in biofilm science, the improvement of its analytical power is required to better evaluate the biofilm structure under different s...
Hydrodynamic conditions affect the proteomic profile of marine biofilms formed ...
Maria João Romeu; Dominguez-Perez, D; Almeida, D; Morais, J; Araujo, MJ; Osorio, H; Alexandre Campos; Vitor Vasconcelos; Filipe MergulhãoProteomic studies on cyanobacterial biofilms can be an effective approach to unravel metabolic pathways involved in biofilm formation and, consequently, obtain more efficient biofouling control strategies. Biofilm development by the filamentous cyanobacterium Toxifilum sp. LEGE 06021 was evaluated on different surfaces, glass and perspex, and at two significant shear rates for marine environments (4 s(-1) and 4...
Influence of Human Milk on Very Preterms' Gut Microbiota and Alkaline Phosphata...
Morais, J; Marques, C; Faria, A; Teixeira, D; Barreiros-Mota, I; Durão, C; Araújo, J; Ismael, S; Brito, S; Cardoso, M; Macedo, I; Pereira, E; Tomé, TThe FEEDMI Study (NCT03663556) evaluated the influence of infant feeding (mother's own milk (MOM), donor human milk (DHM) and formula) on the fecal microbiota composition and alkaline phosphatase (ALP) activity in extremely and very preterm infants (≤32 gestational weeks). In this observational study, preterm infants were recruited within the first 24 h after birth. Meconium and fecal samples were collected at ...