5 documents found, page 1 of 1
Does gestational diabetes mellitus influence the morphological characteristics ...
Souza, Danielle Galdino de; Menezes, Leandro Silva; Macedo, Thayla Estrela de; Oliveira, Gustavo Rodrigues; Brandão, Vanderlene PintoGestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance, with a decrease in insulin sensitivity during pregnancy, with recognition in the second or third trimester of pregnancy and disappearing after delivery. This mini-review is to provide a broad view of some recent studies that investigated the placental morphology in cases of maternal diagnosis of gestational diabetes. A literatu...
An overview on immunogenic cell death in cancer biology and therapy
Rodrigues, Mosar Corrêa; Morais, José Athayde Vasconcelos; Ganassin, Rayane; Oliveira, Giulia Rosa Tavares; Costa, Fabiana ChagasImmunogenic cell death (ICD) is a modality of regulated cell death that is sufficient to promote an adaptive immune response against antigens of the dying cell in an immunocompetent host. An important characteristic of ICD is the release and exposure of damage-associated molecular patterns, which are potent endogenous immune adjuvants. As the induction of ICD can be achieved with conventional cytotoxic agents, ...
Modulation of Chloroquine in nanoparticle uptake: a review
Pacheco, Thyago José Arruda; Morais, José Athayde Vasconcelos; Brandão, Vanderlene Pinto; Rodrigues, Marina Lima; Martins, Maria das NevesThe application of nanotechnology in several areas of medicine has been promising, however, there are still serious problems, such as in the area of oncology, for example. Although nanoparticles can accumulate 10 times more in tumors, less than 1% of the injected dose actually reaches the tumor, as they are retained mainly in the liver and spleen. Liver-specific macrophages, called Kupffer cells, are one of the...
Oral delivery of fish oil in oil-in-water nanoemulsion : development, colloidal...
Santos, Débora S.; Morais, José Athayde Vasconcelos; Vanderlei, Ísis A. C.; Santos, Alexandre S.; Azevedo, Ricardo Bentes de; Muehlmann, Luis AlexandreTo improve the oral absorption of fish oil and test its anti-inflammatory effect, a fish oil nanoemulsion was developed using cis-4,7,10,13,16,19-docosahexaenoic fatty acid as a biomarker for oral administration. The colloidal stability tests of the fish oil nanoemulsion showed an average size of 155.44 nm ± 6.46 (4 °C); 163.04 nm ± 9.97 (25 °C) and polydispersity index 0.22 ± 0.02 (4 °C), 0.21 ± 0.02 (25 °C), ...
Efeito do uso combinado de inibidor de histona desacetilase e terapia fotodinâm...
Morais, José Athayde VasconcelosDissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Pós-Graduação em Nanociência e Nanobiotecnologia, 2019.; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Instituto Nacional de Ciência e Tecnologia (INCT) e Fundação de Apoio à Pesquisa do Distrito Federal (FAP/DF).; Cryptococcus neoformans...