2 documents found, page 1 of 1
Flavonoid Derivatives Targeting BCR-ABL Kinase: Semisynthesis, Molecular Dynami...
Ribeiro, Rayssa; Eloy, Mariana A.; Francisco, Carla S.; Javarini, Clara L.; Ayusso, Gabriela M. [UNESP]; Fonseca, Victor Da Rocha; Romão, WandersonMade available in DSpace on 2022-04-28T19:48:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Background: Natural products have been universally approached in the research of novel trends useful to detail the essential paths of the life sciences and as a stra...
Identifying new isatin derivatives with GSK-3 inhibition capacity through molec...
Britto, Karolinni B.; Francisco, Carla S.; Ferreira, Débora; Borges, Bárbara J. P.; Conti, Raphael; Profeti, Demetrius; Rodrigues, L. R.The semi-synthesis of 11 isatin derivatives was achieved through bimolecular nucleophilic substitution and click chemistry. Seven new compounds were obtained. All chemical structures were determined by infrared spectroscopy (IR), nuclear magnetic resonance spectrometry (NMR) and high-resolution mass spectrometry (HRMS) data. These derivatives were evaluated for their anti-GSK-3 activity and all isatin derivativ...