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Aspirin but not statins is inversely related to gastric cancer with a duration–...

Pastorino, R; Pires Marafon, D; Sassano, M; Hoxhaj, I; Pelucchi, C; Liao, LM; Rabkin, CS; Sinha, R; Lunet, N; Morais, S; Zaridze, D; Maximovich, D

Background: Aspirin and statins have been suggested to have potential chemopreventive effects against gastric cancer (GC), although the results of previous studies have been inconsistent. This study therefore aimed to investigate the association between the use of aspirin and statins and GC. Methods: A pooled analysis of seven case-control studies within the Stomach Cancer Pooling Project, including 3220 cases ...


The association between dietary fiber intake and gastric cancer: a pooled analy...

Collatuzzo, G; Cortez Lainez, J; Pelucchi, C; Negri, E; Bonzi, R; Palli, D; Ferraroni, M; Zhang, ZF; Yu, GP; Lunet, N; Morais, S; López-Carrillo, L

"Purpose: Gastric cancer (GC) is among the leading causes of cancer mortality worldwide. The objective of this study was to investigate the association between dietary fiber intake and GC. Methods: We pooled data from 11 population or hospital-based case-control studies included in the Stomach Cancer Pooling (StoP) Project, for a total of 4865 histologically confirmed cases and 10,626 controls. Intake of dietar...


Baseline data and associations between urinary biomarkers of polycyclic aromati...

Barros, B; Paiva, AM; Oliveira, M; Alves, S; Esteves, F; Fernandes, A; Vaz, J; Slezakova, K; Costa, S; Teixeira, JP; Morais, S

Introduction: Available literature has found an association between firefighting and pathologic pathways leading to cardiorespiratory diseases, which have been linked with exposure to polycyclic aromatic hydrocarbons (PAHs). PAHs are highlighted as priority pollutants by the European Human Biomonitoring Initiative in occupational and non-occupational contexts. Methods: This cross-sectional study is the first to...


Biomonitoring of firefighters' exposure to priority pollutant metal(loid)s duri...

Paiva, AM; Barros, B; Azevedo, R; Oliveira, M; Alves, S; Esteves, F; Fernandes, A; Vaz, J; Alves, MJ; Slezakova, K; Pereira, MDC; Teixeira, JP; Costa, S

Wildland firefighters are exposed to metal(loid)s released during wildfires through vegetation combustion, which also promotes remobilization of accumulated anthropogenic metal(loid)s. Studies biomonitoring metal(loid)s exposure promoted exclusively by wildfire suppression activities are lacking. This work aimed to characterize, for the first time, the impact of real-life wildland firefighting operations on uri...


The protective effect of dietary folate intake on gastric cancer is modified by...

Gonzalez-Palacios, S; Compañ-Gabucio, LM; Torres-Collado, L; Oncina-Canovas, A; García-de-la-Hera, M; Collatuzzo, G; Negri, E; Pelucchi, C; Rota, M

Dietary folate intake has been identified as a potentially modifiable factor of gastric cancer (GC) risk, although the evidence is still inconsistent. We evaluate the association between dietary folate intake and the risk of GC as well as the potential modification effect of alcohol consumption. We pooled data for 2829 histologically confirmed GC cases and 8141 controls from 11 case–control studies from the int...


The Impact of Sleep on Haematological Parameters in Firefighters

Alves, S; Silva, F; Esteves, F; Costa, S; Slezakova, K; Alves, M; Pereira, M; Teixeira, J; Morais, S; Fernandes, A; Queiroga, F; Vaz, J

Sleep is a vital process that impacts biological functions such as cell renewal, bone regeneration, and immune system support. Disrupted sleep can interrupt erythropoiesis, leading to fewer red blood cells, reduced haemoglobin concentration, and decreased haematocrit levels, potentially contributing to haematological disorders. This is particularly concerning for shift workers for example firefighters. While pr...


Biomonitoring of polycyclic aromatic hydrocarbons exposure and short-time healt...

Paiva, AM; Barros, B; Oliveira, M; Alves, S; Esteves, F; Fernandes, A; Vaz, J; Slezáková, K; Teixeira, JP; Costa, S; Morais, S

Human biomonitoring data retrieved from real-life wildland firefighting in Europe and, also, worldwide are scarce. Thus, in this study, 176 Portuguese firefighters were biomonitored pre- and post- unsimulated wildfire combating (average:12–13 h; maximum: 55 h) to evaluate the impact on the levels of urinary polycyclic aromatic hydrocarbons hydroxylated metabolites (OHPAH; quantified by high-performance liquid c...


The contribution of second primary cancers to the mortality of patients with a ...

Gonçalves, E; Fontes, F; Rodrigues, JR; Calisto, R; Bento, MJ; Lunet, N; Morais, S

Purpose: Second primary cancers (SPCs) are estimated to affect nearly 5% of patients with breast cancer within 10 years of their diagnosis. This study aimed to estimate the contribution of SPCs to the mortality of patients with a breast first primary cancer (FPC). Methods: A population-based cohort of 17,210 patients with a breast FPC diagnosed between 2000 and 2010 was followed for SPCs (31/12/2015) and vital ...


Dietary intake of vitamin C and gastric cancer: a pooled analysis within the St...

Sassano, M; Seyyedsalehi, MS; Collatuzzo, G; Pelucchi, C; Bonzi, R; Ferraroni, M; Palli, D; Yu, G-P; Zhang, Z-F; López-Carrillo, L; Lunet, N; Morais, S

Background: Previous studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC. Methods: Fourteen case–control studies were included in the analysis (5362 cases, 11,497 controls...


Second primary cancers among females with a first primary breast cancer: a popu...

Gonçalves, E; Fontes, F; Rodrigues, JR; Calisto, R; Bento, MJ; Lunet, N; Morais, S

"Purpose To estimate the incidence rate of second primary cancers (SPCs) and the cumulative incidence of metachronous [diagnosed > 2 months after a first primary cancer (FPC)] SPCs in patients with a breast FPC, and to compare the incidence of SPC [overall, synchronous (≤ 2 months of the FPC) and metachronous] with that expected in the general female population. Methods A cohort of patients with a breast FPC fr...


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