8 documents found, page 1 of 1
Genossensores Eletroquímicos de Identificação de Espécies Vegetais: Foco no Cas...
Morais, Stephanie; Pereira, Eduarda; Castanheira, Michelle; Santos, Marlene; Domingues, Valentina; Deleure-Matos, Cristina; Barroso, FátimaNeste trabalho, foram desenvolvidos dois genossensores eletroquímicos descartáveis para a identificação de plantas baseado na reação de hibridização entre duas cadeias de ADN complementares de duas espécies de plantas: Erica arborea (urze) e Castanea sativa (castanheiro). Analisando bases de dados públicas, foram selecionados dois pares de sequências especificamente cortadas e desenhadas para identificar o ADN ...
Detecting Candida spp. through an innovative genosensor
Castanheira, Michelle; Morais, Stephanie; Lima, Luís; Santos, Marlene; Barroso, M. Fátima; Santos, MarleneCandida spp. is the second most common cause of invasive fungal infection in hematopoietic stem cell transplantation (HSCT) patients and are associated with high mortality rates, ranging from 40 to 90%. Timely and accurate diagnosis is crucial for successful HSCT treatment. Current diagnostic methods, relying on conventional approaches, have limitations. Molecular and serological tests, although accurate, are t...
Improving honey authentication: Electrochemical genosensors for the detection o...
Morais, Stephanie; Castanheira, Michelle; Santos, Marlene; Domingues, Valentina; Delerue-Matos, Cristina; Barroso, M. Fátima; Santos, MarleneMonofloral honeys, like heather honey, are a highly sought-after ingredient. However, food safety concerns have emerged due to the number of adulterated honeys found in the global market [1,2]. Thus, this work aimed to develop an electrochemical genosensor capable of detecting the residual DNA of Erica arborea (heather flower) in commercial honey samples. Analyzing public databases, a 98-mer E. arborea DNA-targ...
Bdnf-NRF2 crosstalk in depression disorder
Santos, Marlene; Caldevilla, Renato; Morais, Stephanie; Carvalho, Serafim; Medeiros, Rui; Barroso, Maria FátimaThe World Health Organization estimates that major depressive disorder (MDD) affects over 264 million individuals globally, posing a significant public health challenge. Treatment-resistant depression (TRD) represents a severe form of MDD with poor treatment outcomes. Genetic variations are known to impact MDD treatment responses, yet genome-wide association studies have struggled to identify consistent marker ...
Plant honey origin authentication: Use of electrochemical genosensors for food ...
Morais, Stephanie; Pereira, Eduarda; Castanheira, Michelle; Santos, Marlene; Domingues, Valentina; Delerue-Matos, Cristina; Barroso, M. FátimaHoney is a natural high-quality food product consumed worldwide due to its diverse nutritional profile and beneficial medical properties. These factors, along with honey’s unique sweet taste and odour, make it one of the most popular products for a healthy diet. Nevertheless, food fraud is an increasing problem with various impacts on the economy, health, and in the environment, as honey prices are established ...
Electrochemical genosensors as a new approach on plant DNA detection and quanti...
Morais, Stephanie; Castanheira, Michelle; Santos, Marlene; Domingues, Valentina; Delerue-Matos, Cristina; Barroso, M. FátimaHoney is a natural sweet food product with multiple nutritional and medicinal properties making it a healthy alternative to processed sugars. With the consumers’ recent interest and pur-chase of dietary products the global honey market has greatly increased. To keep up with produc-tion, or simply for financial gain, some producers/companies are now blending pure honey with cheaper substances that possess simila...
Design of an electrochemical genosensor for the BDNF gene polymorphism sequence...
Caldevilla, Renato; Morais, Stephanie; Carvalho, Serafim; Medeiros, Rui; Delerue-Matos, Cristina; Cruz, Agostinho; Santos, Marlene; Barroso, M. FátimaThe BDNF gene is associated with high degrees of variability in antidepressant treatments. The Val66Met polymorphism is widely known as a source of this variability, warranting growing interest in genotyping patients that undergo antidepressant treatment to better suit their needs. This paper reports on an electrochemical genosensing platform, based on gold electrodes, capable of detecting this polymorphism, th...
Recent advances in biological properties of brown algae-derived compounds for n...
Silva, Aurora; Cassani, Lucia; Grosso, Clara; Garcia-Oliveira, Paula; Morais, Stephanie; Echave, Javier; Carpena, Maria; Xiao, JianboThe increasing demand for nutraceuticals in the circular economy era has driven the research toward studying bioactive compounds from renewable underexploited resources. In this regard, the exploration of brown algae has shown significant growth and maintains a great promise for the future. One possible explanation could be that brown algae are rich sources of nutritional compounds (polyunsaturated fatty acids,...