5 documents found, page 1 of 1
Design and anticancer properties of new water-soluble ruthenium–cyclopentadieny...
Morais, Tânia; Marques, Fernanda; Madeira, Paulo J. Amorim; Robalo, M.P.; Garcia, Maria HelenaRuthenium complexes are emerging as one of the most promising classes of complexes for cancer therapy. However, their limited aqueous solubility may be the major limitation to their potential clinical application. In view and to contribute to the progress of this field, eight new water-soluble Ru(II) organometallic complexes of general formula [RuCp(mTPPMS)n(L)] [CF3SO3], where mTPPMS = diphenylphosphane-benzen...
Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) ...
Le Gal, Yann; Filatre-Furcate, Agathe; Lorcy, Dominique; Jeannin, Olivier; Roisnel, Thierry; Dorcet, Vincent; Fontinha, Diana; Francisco, DeniseThe biological properties of sixteen structurally related monoanionic gold (III) bis(dithiolene/diselenolene) complexes were evaluated. The complexes differ in the nature of the heteroatom connected to the gold atom (AuS for dithiolene, AuSe for diselenolene), the substituent on the nitrogen atom of the thiazoline ring (Me, Et, Pr, iPr and Bu), the nature of the exocyclic atom or group of atoms (O, S, Se, C(CN)...
Novel "ruthenium cyclopentadienyl" - peptide conjugate complexes against human ...
Machado, João Franco; Machuqueiro, Miguel; Marques, Fernanda; Robalo, M. Paula; Piedade, M. Fatima M.; Garcia, M. Helena; Correia, João D. G.In this work we explored the possibility of improving the selectivity of a cytotoxic Ru complex [RuCp(PPh3)(2,2'-bipy)][CF3SO3] (where Cp = eta(5)-cyclopentadienyl) TM34 towards FGFR(+) breast cancer cells. Molecular dynamics (MD) simulations of TM34 in a phosphatidylcholine membrane model pinpointed the cyclopentadienyl group as a favorable derivatization position for the peptide conjugation approach. Three ne...
First heterobimetallic Cu(i)-dppf complexes designed for anticancer application...
Bravo, Catarina; M. Paula Robalo; Marques, Fernanda; Fernandes, Alexandra; Sequeira, Diogo A.; M. Fatima M. Piedade; Garcia, M. HelenaA new family of eight heterobimetallic Cu(i)-dppf complexes of general formula [Cu(dppf)L][BF4] with dppf = 1,1 '-bis(diphenylphosphino)ferrocene and L representing N,N-, N,O- and N,S-heteroaromatic bidentate ligands have been synthesized and fully characterized by classical analytical, spectroscopic and electrochemical methods. The single crystal structures of [Cu(dppf)(pBI)][BF4] (6), [Cu(dppf)(dpytz)][BF4] (...
Das “Famílias Lançadoras” ao “Ninho Vazio” –percepção dos pais do Stress, Copin...
Morais, TâniaDissertação de Mestrado em Psicologia Clínica, sub-área de especialização em Sistémica, Sáude e Família apresentada à Faculdade de Psicologia e de Ciências da Educação da Universidade de Coimbra; As etapas do ciclo vital da família que nos propomos estudar, “Famílias Lançadoras” e “Ninho Vazio”, são para Alarcão (2002) fases de contracção do agregado familiar, que podem ser encaradas como períodos de desmembram...