4 documents found, page 1 of 1
Impairment of spatial working memory but preservation of recognition memory in ...
Neuparth-Sottomayor, Mariana; Morais, Tatiana P.; Good, Mark; Sebastião, Ana M; Di Giovanni, Giuseppe; Crunelli, Vincenzo; Vaz, Sandra H.Epidemiological studies reveal gender-specific differences in epilepsy. Childhood absence epilepsy (CAE), which is more prevalent in females, is characterized by typical absence seizures (ASs) consisting of brief periods of unconsciousness, associated with 2.5-4 Hz spike-wave discharges (SWDs) in the electroencephalogram (EEG). Children with CAE often present neuropsychological comorbidities, including deficits...
Selective modulation of epileptic tissue by an adenosine A3 receptor‐activating...
Ghosh, Anwesha; Ribeiro Rodrigues, Leonor; Ruffolo, Gabriele; Alfano, Veronica; Domingos, Cátia; Rei, Nádia; Tosh, Dilip K.; Rombo, Diogo M.Background and purpose: Adenosine, through the A1 receptor (A1R), is an endogenous anticonvulsant. The development of adenosine receptor agonists as antiseizure medications has been hampered by their cardiac side effects. A moderately A1R-selective agonist, MRS5474, has been reported to suppress seizures without considerable cardiac action. Hypothesizing that this drug could act through other than A1R and/or th...
Cognitive comorbidities of experimental absence seizures are independent of anx...
Neuparth-Sottomayor, Mariana; Pina, Carolina; Morais, Tatiana P.; Farinha Ferreira, Jorge Miguel; Abreu, Daniela Sofia; Solano, Filipa; Mouro, FranciscoTypical absence seizures (ASs) are brief periods of lack of consciousness, associated with 2.5-4 Hz spike-wave discharges (SWDs) in the EEG, which are highly prevalent in children and teenagers. The majority of probands in these young epileptic cohorts show neuropsychological comorbidities, including cognitive, memory and mood impairments, even after the seizures are pharmacologically controlled. Similar cognit...
Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegener...
Armada-Moreira, Adam; Gomes, Joana I.; Pina, Carolina Campos; Savchak, Oksana K.; Gonçalves-Ribeiro, Joana; Rei, Nádia; Pinto, Sara; Morais, Tatiana P.Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss of neuronal function and cell death. In this process, the shift between normal physiological function and excitotoxicity is largely controlled by astrocytes si...