8 documents found, page 1 of 1
Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvon...
Moro, Isabela Jacob; Gondo, Gabrielle Demmany Gualberto Alexandre; Pierri, Elaíse Gonçalves; Pietro, Rosemeire Cristina Linharis RodriguesConsidering the reported activity of carvone in the literature, this study aimed to evaluate the antimicrobial, cytotoxic and chemopreventive activities of (+)- and (-)-carvone, (+)- and (-)- hydroxydihydrocarvone and α,β-epoxycarvone. (+)-Hydroxydihydrocarvone (HC+), (-)-hydroxydihydrocarvone (HC-) and α,β-epoxycarvone (EP) were obtained by synthesis using (+)-carvone (C+) or (-)-carvone (C-) as precursors. Th...
Evaluation of the cytotoxicity of structurally correlated p-menthane derivatives
Andrade, Luciana Nalone; Lima, Tamires Cardoso; Amaral, Ricardo Guimarães; Pessoa, Cláudia do Ó; Moraes Filho, Manoel Odorico de; Soares, Bruno MarquesCompounds isolated from essential oils play an important role in the prevention and treatment of cancer. Monoterpenes are natural products, and the principal constituents of many essential oils. The aim of this study was to investigate the cytotoxic potential of p-menthane derivatives. Additionally, analogues of perillyl alcohol, a monoterpene with known anticancer activity, were evaluated to identify the molec...
Avaliação da toxicidade aguda do epóxilimoneno em camundongos adultos
Almeida, Antonia Amanda Cardoso de; Carvalho, Rusbene Bruno Fonseca de; Sousa, Damião Pergentino de; Souza, Geane Felix de; Oliveira, Johanssy da SilvaIntroduction: the biodiversity of global flora provides important molecules for the treatment and prevention of various human diseases, but most often their toxicities are not evaluated. Objective: evaluate the toxicity of monoterpenoid limonene epoxidein mice treated acutely with repeated doses (25, 50 and 75 mg/kg) orally on hematological and biochemical parameters. Methods: forty mice divided infour groups (...
Phytol, a diterpene alcohol from chlorophyll, as a drug against neglected tropi...
Moraes, Josué de; Oliveira, Rosimeire Nunes de; Costa, Jéssica P.; Gomes Junior, Antonio Luiz; Sousa, Damião Pergentino de; Freitas, Rivelilson M.Background: Schistosomiasis is a major endemic disease that affects hundreds of millions worldwide. Since the treatment and control of this parasitic disease rely on a single drug, praziquantel, it is imperative that new effective drugs are developed. Here, we report that phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, possesses promising antischistosomal pro...
Anti-ulcer activity of essential oil constituents
Oliveira, Francisco de Assis; Andrade, Luciana Nalone; Sousa, Élida Batista Vieira de; Sousa, Damião Pergentino deEssential oils have attracted considerable worldwide attention over the last few decades. These natural products have wide-ranging pharmacological activities and biotechnological applications. Faced with the need to find new anti-ulcer agents and the great effort on the development of drugs for the treatment of ulcers, in this review, the antiulcer activities of 21 bioactive compounds found in essential oils ar...
TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate
Rios, Emiliano Ricardo Vasconcelos; Rocha, Nayrton Flávio Moura; Carvalho, Alyne Mara Rodrigues; Vasconcelos, Leonardo Freire; Dias, Marília LeiteBackground: Citronellyl acetate (CAT), a monoterpene product of the secondary metabolism of plants, has been shown in the literature to possess several different biological activities. However, no antinociceptive abilities have yet been discussed. Here, we used acute pain animal models to describe the antinociceptive action of CAT. Methods: The acetic acid-induced writhing test and the paw-licking test, in whic...
Antinociceptive activity of carvacrol (5-isopropyl-2- methylphenol) in mice
Melo, Francisca Helvira Cavalcante; Rios, Emiliano Ricardo Vasconcelos; Rocha, Nayrton Flávio Moura; Citó, Maria do Carmo de OliveiraObjectives Carvacrol (5-isopropyl-2-methylphenol) is a monoterpenic phenol which is present in the essential oil of oregano and thyme.We have investigated the behavioural effects of carvacrol in animal models of pain, such as acetic acidinduced abdominal constriction, formalin and hot-plate tests in mice. The spontaneous motor activity of animals treated with carvacrol was investigated using open-field and rota...
Anti-inflammatory and redox-protective activities of citronellal
Melo, Mônica Santos de; Guimarães, Adriana Gibara; Santana, Michele Fraga de; Barreto, Rosana de Souza Siqueira; Lima, Amanda do Carmo Bion deThe anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p < 0.05) by i.p. admi...