5 documents found, page 1 of 1
Improving the drug-likeness of inspiring natural products - evaluation of the a...
Morais, Thiago R.; Conserva, Geanne A. Alves; Varela, Marina T.; Costa-Silva, Thais A.; Thevenard, Fernanda; Ponci, Vitor; Fortuna, AnaNeolignan licarin A (1) was isolated from leaves of Nectandra oppositifolia (Lauraceae) and displayed activity against trypomastigote forms of the etiologic agent of American trypanosomiasis, Trypanosoma cruzi. Aiming for the establishment of SAR, five different compounds (1a - 1e) were prepared and tested against T. cruzi. The 2-allyl derivative of licarin A (1d) exhibited higher activity against trypomastigot...
Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira bac...
Bruno de Sousa, Carolina; Gangadhar, Katkam N.; Morais, Thiago R.; Conserva, Geanne A.A.; Vizetto-Duarte, Catarina; Pereira, Hugo; Laurenti, Márcia D.Made available in DSpace on 2018-12-11T17:09:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); The development of novel drugs for the treatment of leishmaniases continues to be crucial to overcome the severe impacts of these diseases on human and animal health. Seve...
Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira bac...
Sousa, Carolina Bruno de; Gangadhar, Katkam N.; Morais, Thiago R.; Conserva, Geanne A. A.; Vizetto-Duarte, C; Pereira, H.; Laurenti, Marcia D.The development of novel drugs for the treatment of leishmaniases continues to be crucial to overcome the severe impacts of these diseases on human and animal health. Several bioactivities have been described in extracts from macroalgae belonging to the Cystoseira genus. However, none of the studies has reported the chemical compounds responsible for the antileishmanial activity observed upon incubation of the ...
Cystoseira algae (Fucaceae): update on their chemical entities and biological a...
Bruno De Sousa, Carolina; Gangadhar N. Katkam, Dr.; Macridachis, Jorge; Pavao, Madalena; Morais, Thiago R.; Campino, LeneaCystoseira (Sargassaceae) is a genus of marine brown algae composed of about 40 species, which is distributed along the Eastern Atlantic and Mediterranean coasts. The biological potential of the Cystoseira genus has been investigated and several activities have been reported. Chemically, this genus contains a wide variety of secondary metabolites, such as terpenoids, steroids, phlorotannins and phenolic compoun...
Can macroalgae provide promising anti-tumoral compounds? A closer look at Cysto...
Vizetto-Duarte, C; Custódio, Luísa; Acosta, Gerardo; Lago, João H. G.; Morais, Thiago R.; Sousa, Carolina Bruno de; Gangadhar, Katkam N.Marine organisms are a prolific source of drug leads in a variety of therapeutic areas. In the last few years, biomedical, pharmaceutical and nutraceutical industries have shown growing interest in novel compounds from marine organisms, including macroalgae. Cystoseira is a genus of Phaeophyceae (Fucales) macroalgae known to contain bioactive compounds. Organic extracts (hexane, diethyl ether, ethyl acetate and...