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Escuelas de frontera, escuelas sin fronteras: compartiendo lenguas y culturas

Araújo e Sá, M. H. (coord.); Matesanz del Barrio, Maria (coord.); Martins, Viviane Ferreira (coord.); Arias, Ana Isabel; Cardoso, Ana Margarida

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Date: 2025   |   Origin: RIA - Repositório Institucional da Universidade de Aveiro
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Unraveling fiscalin derivatives' interactions with P-glycoprotein: a computatio...

Veiga-Matos, Jéssica; dos Santos, Daniel J. V. A.; Sousa, Emília; Morales, Ana; Prieto, Marta; Remião, Fernando; Silva, Renata

Background: P-glycoprotein (P-gp), a crucial efflux transporter located on the apical membrane of vital barrier tissues, plays a critical role in the detoxification of several endobiotics and xenobiotics [1,2]. Notably, fiscalin derivatives exhibit diverse interactions with P-gp, demonstrating inhibitory or activating effects. This interaction leads to a reduction or increase in the transported substrate levels...

Date: 2024   |   Origin: Scientific Letters
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