3 documents found, page 1 of 1
Epilepsy in Neurodegenerative Diseases: Related Drugs and Molecular Pathways
Cano, Amanda; Fonseca, Elena; Ettcheto, Miren; Sánchez-López, Elena; de Rojas, Itziar; Alonso-Lana, Silvia; Morató, Xavier; Souto, Eliana B.Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. It is the second most prevalent neurological disease, with 50 million people affected around the world, and 30% of all epilepsies do not respond to available treatments. Currently, the main hypothesis about the molecular processes that trigger epileptic seizures and promote the neurotoxic effects tha...
Epilepsy in neurodegenerative diseases: related drugs and molecular pathways
Cano, Amanda; Fonseca, Elena; Ettcheto, Miren; Sánchez-López, Elena; de Rojas, Itziar; Alonso-Lana, Silvia; Morató, Xavier; Souto, Eliana B.Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. It is the second most prevalent neurological disease, with 50 million people affected around the world, and 30% of all epilepsies do not respond to available treatments. Currently, the main hypothesis about the molecular processes that trigger epileptic seizures and promote the neurotoxic effects tha...
The Parkinson's disease-associated GPR37 receptor interacts with striatal adeno...
Morató, Xavier; Luján, Rafael; López-Cano, Marc; Gandía, Jorge; Stagljar, Igor; Watanabe, Masahiko; Cunha, Rodrigo A.; Fernández-Dueñas, VíctorG protein-coupled receptor 37 (GPR37) is an orphan receptor associated to Parkinson's disease (PD) neuropathology. Here, we identified GPR37 as an inhibitor of adenosine A2A receptor (A2AR) cell surface expression and function in vivo. In addition, we showed that GPR37 and A2AR do oligomerize in the striatum. Thus, a close proximity of GPR37 and A2AR at the postsynaptic level of striatal synapses was observed b...