21 documents found, page 1 of 3
Water-Soluble Saccharina latissima Polysaccharides and Relation of Their Struct...
Moreira, Ana S. P.; Gaspar, Diana; Ferreira, Sónia S.; Correia, Alexandra; Vilanova, Manuel João Rua; Perrineau, Marie-Mathilde; Kerrison, Philip D.Brown macroalgae are an important source of polysaccharides, mainly fucose-containing sulphated polysaccharides (FCSPs), associated with several biological activities. However, the structural diversity and structure-function relationships for their bioactivities are still undisclosed. Thus, the aim of this work was to characterize the chemical structure of water-soluble Saccharina latissima polysaccharides and ...
Potential of Coccolithophore microalgae as fillers in starch-based films for ac...
Moreira, Ana S. P.; Gonçalves, Joana; Sousa, Francisco; Maia, Inês Beatriz; Pereira, Hugo; Silva, Joana; Coimbra, Manuel A.; Ferreira, PaulaCoccolithophore microalgae, such as Emiliania huxleyi (EHUX) and Chrysotila pseudoroscoffensis (CP), are composed of calcium carbonate (CaCO3) and contain bioactive compounds that can be explored to produce sustainable food packaging. In this study, for the first time, these microalgae were incorporated as fillers in starch-based films, envisioning the development of biodegradable and bioactive materials for fo...
Mitochondrial fatty acid β-oxidation disorders: from disease to lipidomic studi...
Guerra, Inês M. S.; Ferreira, Helena B.; Melo, Tânia; Rocha, Hugo; Moreira, Sónia; Diogo, Luísa; Domingues, Maria Rosário; Moreira, Ana S. P.Fatty acid oxidation disorders (FAODs) are inborn errors of metabolism (IEMs) caused by defects in the fatty acid (FA) mitochondrial β-oxidation. The most common FAODs are characterized by the accumulation of medium-chain FAs and long-chain (3-hydroxy) FAs (and their carnitine derivatives), respectively. These deregulations are associated with lipotoxicity which affects several organs and potentially leads to l...
Chrysotila pseudoroscoffensis as a source of high-value polar lipids with antio...
Moreira, Ana S. P.; Gonçalves, Joana; Conde, Tiago A.; Couto, Daniela; Melo, Tânia; Maia, Inês Beatriz; Pereira, Hugo; Silva, JoanaMicroalgae are emerging as sustainable sources of a wide range of high-value compounds. However, the knowledge about microalgae polar lipids is still limited, despite their interest due to their chemical diversity and bioactivity. This study shows, for the first time, the polar lipidome of the haptophyte microalga Chrysotila pseudoroscoffensis unveiled by using hydrophilic interaction liquid chromatography-high...
Plasma phospholipidomic profile differs between children with phenylketonuria a...
Guerra, Inês M. S.; Diogo, Luísa; Pinho, Marisa; Melo, Tânia; Domingues, Pedro; Domingues, M. Rosário; Moreira, Ana S. P.Phenylketonuria (PKU) is a disease of the catabolism of phenylalanine (Phe), caused by an impaired function of the enzyme phenylalanine hydroxylase. Therapeutics is based on the restriction of Phe intake, which mostly requires a modification of the diet. Dietary restrictions can lead to imbalances in specific nutrients, including lipids. In the present study, the plasma phospholipidome of PKU and healthy childr...
Polar lipids of commercial Ulva spp. of different origins: profiling and releva...
Moreira, Ana S. P.; da Costa, Elisabete; Melo, Tânia; Lopes, Diana; Pais, Adriana C. S.; Santos, Sónia A. O.; Pitarma, Bárbara; Mendes, MadalenaMacroalgae of the genus Ulva have long been used as human food. Local environmental conditions, among other factors, can have an impact on their nutrient and phytochemical composition, as well as on the value of the seaweed for food and non-food applications. This study is the first to initiate a comparison between commercial Ulva spp. from different European origins, France (FR, wild-harvested Ulva spp.), and ...
Seasonal plasticity of the polar lipidome of Ulva rigida cultivated in a sustai...
Moreira, Ana S. P.; Costa, Elisabete da; Melo, Tânia; Sulpice, Ronan; Cardoso, Susana M.; Pitarma, Bárbara; Pereira, Rui; Abreu, Maria H.Green macroalgae of the genus Ulva, commonly known as sea lettuces, are currently traded worldwide for multiple applications, including human consumption. In this work, we evaluated the seasonal variation of the total content of lipids, esterified fatty acids (FAs) and polar lipids (the major carriers of FAs) at the level of the classes and molecular species of Ulva rigida cultivated in Portugal in a land-based...
Lipids and phenylketonuria: current evidences pointed the need for lipidomics s...
Guerra, Inês M. S.; Ferreira, Helena B.; Neves, Bruna; Melo, Tânia; Diogo, Luísa M.; Domingues, M. Rosário; Moreira, Ana S. P.Phenylketonuria (PKU) is the most prevalent inborn error of amino acid metabolism. The disease is due to the deficiency of phenylalanine (Phe) hydroxylase activity, which causes the accumulation of Phe. Early diagnosis through neonatal screening is essential for early treatment implementation, avoiding cognitive impairment and other irreversible sequelae. Treatment is based on Phe restriction in the diet that s...
The unique lipidomic signatures of Saccharina latissima can be used to pinpoint...
Monteiro, João P.; Rey, Felisa; Melo, Tânia; Moreira, Ana S. P.; Arbona, Jean-François; Skjermo, Jorunn; Forbord, Silje; Funderud, Jon; Raposo, DiogoThe aquaculture of macroalgae for human consumption and other high-end applications is experiencing unprecedented development in European countries, with the brown algae Saccharina latissima being the flag species. However, environmental conditions in open sea culture sites are often unique, which may impact the biochemical composition of cultured macroalgae. The present study compared the elemental composition...
The polar lipidome of cultured Emiliania huxleyi: a source of bioactive lipids ...
Aveiro, Susana S.; Melo, Tânia; Figueiredo, Ana; Domingues, Pedro; Pereira, Hugo; Maia, Inês Beatriz; Silva, Joana; Domingues, M. RosárioPolar lipids from microalgae have aroused greater interest as a natural source of omega-3 (n-3) polyunsaturated fatty acids (PUFA), an alternative to fish, but also as bioactive compounds with multiple applications. The present study aims to characterize the polar lipid profile of cultured microalga Emiliania huxleyi using hydrophilic interaction liquid chromatography coupled with high-resolution mass spectrome...