5 documents found, page 1 of 1
Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific...
Santos, Catiule de Oliveira; Costa, Sidnei Ferro [UNESP]; Souza, Fabiana Santana; Mendes, Jessica Mariane FerreiraMade available in DSpace on 2021-06-25T11:10:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; rIL-10 plays a major role in restricting exaggerated inflammatory and immune responses, thus preventing tissue damage. However, the restriction of inflammatory and immune responses by IL-10 can also favor the development and/or persistence of chronic infections or neoplasms. Dogs that succumb to canine ...
A novel platinum complex containing a piplartine derivative exhibits enhanced c...
Oliveira, Maiara de Souza; Barbosa, Marília Imaculada Frazão; Souza, Thiago Belarmino de; Moreira, Diogo Rodrigo de Magalhães; Martins, Felipe TerraPiplartine (piperlongumine) is a plant-derived compound found in some Piper species that became a novel potential antineoplastic agent. In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigat...
Cytotoxic and toxicological effects of phthalimide derivatives on tumor and nor...
Ferreira, Paulo Michel Pinheiro; Costa, Patrícia Marçal da; Costa, Arinice de Menezes; Lima, Daisy Jereissati Barbosa; Drumond, Renata RosadoEleven phthalimide derivatives were evaluated with regards to their antiproliferative activity on tumor and normal cells and possible toxic effects. Cytotoxic analyses were performed against murine tumors (Sarcoma 180 and B-16/F-10 cells) and peripheral blood mononuclear cells (PBMC) using MTT and Alamar Blue assays. Following, the investigation of cytotoxicity was executed by flow cytometry analysis and antitu...
Ruthenium(II) complexes of 1,3-thiazolidine-2-thione : cytotoxicity against tum...
Correa, Rodrigo de Souza; Silva, Monize Martins da; Graminha, Angelica Ellen; Meira, Cássio Santana; Santos, Jamyle Andrade Ferreira dosThree newmixed and mononuclear Ru(II) complexes containing 1,3-thiazolidine-2-thione (tzdtH) were synthesized and characterized by spectroscopic analysis, molar conductivity, cyclic voltammetry, high-resolution electrospray ionization mass spectra and X-ray diffraction. The complexes presented unique stereochemistry and the proposed formulae are: [Ru(tzdt)(bipy)(dppb)]PF6 (1), cis-[Ru(tzdt)2(PPh3)2] (2) and tra...
Planejamento estrutural, síntese e avaliação das propriedades tripanocidas de 2...
Moreira, Diogo Rodrigo de MagalhãesCNPq FACEPE INCT-Dengue; A doença de Chagas é uma infecção parasitária sistêmica causada pelo protozoário Trypanosoma cruzi. Em torno de 30–40 % dos pacientes infectados evoluem para a fase crônica sintomática, resultando em cardiomiopatias. O benznidazol é o único medicamento disponível para o tratamento durante a fase aguda e crônica assintomática, contudo não possui eficácia comprovada durante a fase crônica...