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Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal do...

Hagmann, V; Sommer, S; Fabian, P; Bierlmeier, J; van Treel, N; Mootz, H; Schwarzer, D; Azevedo, JE; Dodt, G

Peroxisomal matrix proteins contain either a peroxisomal targeting sequence 1 (PTS1) or a PTS2 that are recognized by the import receptors PEX5 and PEX7, respectively. PEX5 transports the PTS1 proteins and the PEX7/PTS2 complex to the docking translocation module (DTM) at the peroxisomal membrane. After cargo release PEX5 is monoubiquitinated and extracted from the peroxisomal membrane by the receptor export ma...

Date: 2018   |   Origin: Repositório Aberto da Universidade do Porto
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