5 documents found, page 1 of 1
Pigments profile and antioxidant potential of extremophile cyanobacteria isolat...
Silva, Raquel; Gonçalves, Talita; Morone, Janaína; Moreira, Gabriela Alves; Morais, João; Hentschke, Guilherme ScottaCyanobacteria are ancient and prolific microorganisms for which the current knowledge remains limited. The present work constitutes the first report on the presence of the cyanobacteria Tolypothrix sp. LEGE 221228, Nostoc sp. LEGE 221229, Scytonema sp. LEGE 221230 and Drouetiella sp. LEGE 221231 in the volcanic crater lake in Chichonal (Chiapas-Mexico), and in the characterization of their pigments profile and ...
Discovery of new cyanobacterial natural products with bioactivity
Moreira, Gabriela AlvesO cancro e a resistência antimicrobiana são dois dos principais problemas de saúde na sociedade atual, sendo por isso imprescindível a procura de novos tratamentos mais eficazes nestas áreas terapêuticas. Os produtos naturais têm sido um importante recurso para obtenção de compostos com atividade biológica, incluindo compostos com propriedades anticancerígenas e antimicrobianas. Neste contexto, as cianobactéria...
Synthesis and antimetastatic activity evaluation of cinnamic acid derivatives c...
Lima, Graziela Domingues de Almeida; Rodrigues, Michelle Peixoto; Moreira, Gabriela Alves; Mendes, Tiago Antônio de Oliveira; Siqueira, Raoni PaisIt is herein described the preparation and evaluation of antimetastatic activity of twenty-six cinnamic acid derivatives containing 1,2,3-triazolic portions. The compounds were prepared using as the key step the Copper(I)-catalyzed azide (A)-alkyne (A) cycloaddition (C) (CuAAC reaction), also known as click reaction, between alkynylated cinnamic acid derivatives and different benzyl azides. The reactions were c...
Antimetastatic effect of the pharmacological inhibition of serine/arginine-rich...
Moreira, Gabriela Alves; Lima, Graziela Domingues de Almeida; Siqueira, Raoni Pais; Barros, Marcus Vinícius de AndradeThe Serine/arginine-rich protein kinases (SRPK) are involved in pre-mRNA splicing control through the phosphorylation of the SR protein family of splicing factors. Over the last years, several studies have shown the relevance of SRPK for human cancers and their potential as promising drug targets. In this context, we have previously selected three trifluoromethyl arylamides (named here as SRVIC24, SRVIC30 and S...
Splicing regulators and their roles in cancer biology and therapy
Silva, Maria Roméria da; Moreira, Gabriela Alves; Silva, Ronni Anderson Gonçalves da; Barbosa, Éverton de Almeida Alves; Siqueira, Raoni PaisAlternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other process...