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IgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures

Correia, Catarina; Moreira, Hélder; Almeida, Nuno; Soares, Marta; Cipriano, Maria Augusta; Figueiredo, Pedro

IgG4-related disease is a recently recognized autoimmune systemic disorder that has been described in various organs. The disease is characterized histologically by a dense lymphoplasmacytic infiltrate with IgG4-positive cells, storiform fibrosis, obliterative phlebitis, and can be associated with space-occupying lesions. IgG4-related disease involving the upper gastrointestinal tract is rare. We report the cas...


IgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures

Correia, Catarina; Moreira, Hélder; Almeida, Nuno; Soares, Marta; Cipriano, Augusta; Figueiredo, Pedro

IgG4-related disease is a recently recognized autoimmune systemic disorder that has been described in various organs. The disease is characterized histologically by a dense lymphoplasmacytic infiltrate with IgG4-positive cells, storiform fibrosis, obliterative phlebitis, and can be associated with space-occupying lesions. IgG4-related disease involving the upper gastrointestinal tract is rare. We report the cas...


A Case of Severe Cholestasis due to Hepatic AL Amyloidosis

Dias, Teresa; Ferreira, Diana; Moreira, Hélder; Nascimento, Telma; Santos, Arsénio; Carvalho, Armando

Introduction: Immunoglobulin light chain-associated amyloidosis results from extracellular tissue deposition of fibrilforming monoclonal immunoglobulin light chains, secreted by a clone of plasma cells. Although the liver is often involved histologically, most cases are clinically asymptomatic, and severe intrahepatic cholestasis as the primary manifestation of the disease is rare. Clinical Case: We report an u...


Cloud-centric networking using virtualization and resource sharing

Maddali, Bala Krishna; Corujo, Daniel; Gomes, Diogo; Barraca, João Paulo; Moreira, Hélder


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