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Impact of Truncated O-glycans in Gastric-Cancer-Associated CD44v9 Detection
Moreira, IB; Pinto, F; Gomes, C; Campos, D; Reis, CACD44 variant isoforms are often upregulated in cancer and associated with increased aggressive tumor phenotypes. The CD44v9 is one of the major protein splice variant isoforms expressed in human gastrointestinal cancer cells. Immunodetection of CD44 isoforms like CD44v9 in tumor tissue is almost exclusively performed by using specific monoclonal antibodies. However, the structural variability conferred by both ...
Date: 2020
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Origin: Repositório Aberto da Universidade do Porto