81 documents found, page 1 of 9
PFAS biodegradation by Labrys portucalensis F11: evidence of chain shortening a...
Wijayahena, Mindula K.; Moreira, Irina S.; Castro, Paula M. L.; Dowd, Sarah; Marciesky, Melissa I.; Ng, Carla; Aga, Diana S.The biodegradation of three per- and polyfluoroalkyl substances (PFAS), namely perfluorooctane sulfonic acid (PFOS), 6:2-fluorotelomer sulfonic acid (6:2 FTS), and 5:3-fluorotelomer carboxylic acid (5:3 FTCA), were evaluated using Labrys portucalensis F11, an aerobic bacteria known to defluorinate fluorine-containing compounds. Cultures of L. portucalensis F11 were grown in minimal salts media and treated with ...
Exploring the biodegradation of PET in mangrove soil and its intermediates by e...
Saidu, Muhammad Bashir; Moreira, Irina S.; Amorim, Catarina L.; Wu, Rongben; Ho, Yuen-Wa; Fang, James Kar-Hei; Castro, Paula M. L.; Gonçalves, DavidThe biodegradation of Polyethylene terephthalate (PET) is important due to the environmental impact of plastic waste. This study investigates the degradation of PET films in soil microcosms, with and without mangrove plants, and with mangrove plants bioaugmented with a bacterial consortium (Bacillus sp.- GPB12 and Enterococcus sp.- WTP31B-5) while following the evolution of soil microcosm microbiome. The abilit...
Bacterial degradation of perfluorooctane sulfonic acid (PFOS): detection of by-...
Wijayahena, Mindula K.; Moreira, Irina S.; Wallace, Joshua S.; Castro, Paula M. L.; Aga, Diana S.Introduction: Per- and poly-fluoroalkyl substances (PFAS) are highly fluorinated synthetic chemicals with a wide variety of uses1,2. The carbon- fluorine bonds exhibit very high bond dissociation energies: around 536 kJ/mol, making PFAS generally resistant to degradation by oxidation, thermal treatment, and biological mechanisms, which has led to their classification as “forever chemicals”3. Strategies to enhan...
PFAS biodegradation by Labrys portucalensis F11: identification of metabolites ...
Wijayahena, Mindula K.; Moreira, Irina S.; Castro, Paula M. L.; Aga, Diana S.Introduction Per- and poly-fluoroalkyl substances (PFAS) are highly fluorinated synthetic chemicals with a wide variety of uses1,2. The carbon- fluorine bonds exhibit very high bond dissociation energies: around 536 kJ/mol, making PFAS generally resistant to degradation, which has led to their classification as “forever chemicals”3. Strategies to enhance the biodegradation of these compounds are of great intere...
Microbial consortia selection for the development of an innovative nature-based...
Moreira, Irina S.; Novo, Beatriz; Monteiro, Pedro; Pinto, Glória; Castro, Paula M. L.; Alves, Artur; Tacão, Marta; Alves, MartaAir pollutants, like benzene, toluene, and xylene (BTX), pose significant health and environmental risks being associated with 6.7 million premature deaths annually. Despite plants natural air purification capabilities in green infrastructures, high pollution levels in cities can hinder urban greening when tolerance levels are exceeded. Therefore, this study aimed to develop plant-beneficial microbial consortia...
Biodegradation of perfluorooctane sulfonic acid (PFOS) by the bacterial strain ...
Wijayahena, Mindula K.; Moreira, Irina S.; Wallace, Joshua S.; Castro, Paula M. L.; Aga, Diana S.Introduction: Per- and poly-fluoroalkyl substances (PFAS) are highly fluorinated synthetic chemicals with a wide variety of uses1,2. The carbon-fluorine bonds exhibit very high bond dissociation energies: around 536 kJ/mol, making PFAS generally resistant to degradation by oxidation, thermal treatment, and biological mechanisms, which has led to their classification as “forever chemicals”3. Strategies to enhanc...
The World of GPCR dimers - Mapping dopamine receptor D2 homodimers in different...
Bueschbell, Beatriz; Magalhães, Pedro R.; Barreto, Carlos A. V.; Melo, Rita; Schiedel, Anke C.; Machuqueiro, Miguel; Moreira, Irina S.G protein-coupled receptors (GPCRs) are known to dimerize, but the molecular and structural basis of GPCR dimers is not well understood. In this study, we developed a computational framework to generate models of symmetric and asymmetric GPCR dimers using different monomer activation states and identified their most likely interfaces with molecular details. We chose the dopamine receptor D2 (D2R) homodimer as a...
MUG: A mutation overview of GPCR subfamily A17 receptors
Caniceiro, Ana B.; Bueschbell, Beatriz; Barreto, Carlos A. V.; Preto, Antonio J.; Moreira, Irina S.G protein-coupled receptors (GPCRs) mediate several signaling pathways through a general mechanism that involves their activation, upholding a chain of events that lead to the release of molecules responsible for cytoplasmic action and further regulation. These physiological functions can be severely altered by mutations in GPCR genes. GPCRs subfamily A17 (dopamine, serotonin, adrenergic and trace amine recepto...
DELFOS-drug efficacy leveraging forked and specialized networks-benchmarking sc...
Piochi, Luiz Felipe; Preto, Antonio J.; Moreira, Irina S.Motivation: Cancer is currently one of the most notorious diseases, with over 1 million deaths in the European Union alone in 2022. As each tumor can be composed of diverse cell types with distinct genotypes, cancer cells can acquire resistance to different compounds. Moreover, anticancer drugs can display severe side effects, compromising patient well-being. Therefore, novel strategies for identifying the opti...
Bioaugmentation of aerobic granular sludge with dye-decolorizing yeast for text...
Mendes, Marta; Moreira, Irina S.; Moreira, Patrícia; Pintado, Manuela; Castro, Paula M. L.A sequencing batch reactor (SBR) inoculated with activated sludge and bioaugmented with a dye-decolorizing yeast strain—Yarrowia lipolytica (HOMOGST27AB) was assembled to form yeastbioaugmented aerobic granular sludge (AGS). The bioaugmented AGS-SBR was operated for the treatment of synthetic saline wastewater (12 g L1) intermittently fed with a reactive textile dye (Navy Everzol ED) at 25, 15, and 7.5 mg L1. D...