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The recombinant Lactococcus lactis oral vaccine induces protection against C. d...
Moreira, Maira Aparecida S.; Guo, Shanguang; Yan, Weiwei; McDonough, Sean P.; Lin, Nengfeng; Wu, Katherine J.; He, Hongxuan; Xiang, Hua; Yang, MaoshengClostridium difficile infection (CDI) causes nosocomial antibiotic-associated diarrhea and colitis in the developed world. Two potent cytotoxins, toxin A (TcdA) and toxin B (TcdB) are the virulence factors of this disease and can be a good vaccine candidate against CDI. In the present study, we genetically engineered Lactococcus lactis to express the nontoxic, recombinant fragments derived from TcdA and TcdB C-...
Date: 2018
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Origin: Oasisbr