3 documents found, page 1 of 1
The role of endoplasmic reticulum in amyloid precursor protein processing and t...
Plácido, A. I.; Pereira, C. M. F.; Duarte, A. I.; Candeias, E.; Correia, S. C.; Santos, R. X.; Carvalho, C.; Cardoso, S.; Oliveira, C. R.The endoplasmic reticulum (ER) is the principal organelle responsible for the proper folding/processing of nascent proteins and perturbed ER function leads to a state known as ER stress. Mammalian cells try to overcome ER stress through a set of protein signaling pathways and transcription factors termed the unfolded protein response (UPR). However, under unresolvable ER stress conditions, the UPR is hyperactiv...
Molecular mechanisms beyond glucose transport in diabetes-related male infertility
Alves, M. G.; Martins, A. D.; Rato, L.; Moreira, P. I.; Socorro, S.; Oliveira, P. F.Diabetes mellitus (DM) is one of the greatest public health threats in modern societies. Although during a few years it was suggested that DM had no significant effect in male reproductive function, this view has been challenged in recent years. The increasing incidence of DM worldwide will inevitably result in a higher prevalence of this pathology in men of reproductive age and subfertility or infertility asso...
Neurofilament proteins in neurodegenerative diseases
Liu, Q.; Xie, F.; Siedlak, S. L.; Nunomura, A.; Honda, K.; Moreira, P. I.; Zhua, X.; Smith, M. A.; Perry, G.The function of neurofilaments, the major component in large myelinated neurons, is not well understood even though they were discovered as structures over 100 years ago. Recent studies have suggested that neuro-filaments are closely related to many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson disease Alzheimer disease, and diabetes. Using in vitro assays, cultures and transgenic...