83 documents found, page 1 of 9
Association between placental weight and birthweight, adjusted for parity, sex ...
Santos, Inês; Moreira, Rui; Gonçalves, Inês Sarmento; Dias, Cláudia Camila; Ramalho, CarlaPlacental weight has been studied as an indicator of placental function, correlating with birthweight and perinatal outcomes. The fetal-to-placental ratio (FPR) reflects the adaptation to hypoxemia and fetal growth needs. This study aims to assess the association between placental weight and birthweight, adjusting for parity, fetal sex and PAPP-A. A retrospective cohort study was conducted at a tertiary univers...
Sequence alignment: Comparative analysis of algorithms in KRAS genetic mutations
Pereira, Ana Rita; Lopes, Carlos; Oliveira, Catarina; Pereira, Gonçalo; Moreira, Rui; Faria, Brígida Mónica; Faria, Brigida MonicaFor this study a program was developed in Python on biological sequence alignment, considering the application of algorithms in the genetic analysis of Kristen rat sarcoma viral oncogene (KRAS) and its main mutations associated with cancer. The KRAS gene, like other genes in the same family, is responsible for encoding proteins that regulate cell proliferation, differentiation, and apoptosis. The algorithms emp...
Π-Π stacking stabilized polymeric micelles for hydrophobic drug delivery in the...
Alves, Ana G. Gomes; Varela-Moreira, Aida; Cruz, Tânia; Duarte, Margarida; Castro, Helena; Moreira, Rui; Ressurreição, Ana S.; Storm, GertCurrent control strategies for leishmaniases − a group of diseases caused by protozoan parasites of the genus Leishmania − rely on chemotherapy, which is often associated with significant drawbacks, including severe side effects and limited drug efficacy. The public health impact of leishmaniases underscores the urgent need for new therapeutic approaches. Quinoline-(1H)-imines have emerged as promising lead com...
Novel knee implant fixation technology: 3D printed foamed bioactive screw/elect...
Rodrigues, Mafalda; Moreira, Rui; Silva, Inês V.; Duarte, Marta M.; Ribeiro, Viviana P.; Oliveira, Ana L.; Costa, João B.Introduction: Musculoskeletal injuries, widespread across all ages, genders, and sociodemographic groups1, are prevalent in the knee joint. Besides the conservative treatments and physiotherapy, several degenerative and traumatic knee injuries require surgical intervention2. To address one of the most significant challenges in surgical orthopaedic procedures, long-term implant fixation3, an innovative solution ...
3D printed bioactive interference screw and PCL bio-filler for ligament fixation
Rodrigues, Mafalda; Moreira, Rui; Silva, Inês V.; Duarte, Marta M.; Ribeiro, Viviana P.; Oliveira, Ana L.; Costa, João B.Musculoskeletal injuries, widespread across all ages, genders and sociodemographic groups, are prevalent in the knee joint and require a range of treatments - from conservative methods to surgical interventions, such as meniscal resection, repair, reconstruction or tissue engineering (TE) approaches. To address one of the most significant challenges in orthopedic procedures – long-term implant fixation – an inn...
Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A3 C...
da Silva, Gustavo; Luz, André F. S.; Duarte, Denise; Fontinha, Diana; Silva, Vera L. M.; Almeida Paz, Filipe A.; Madureira, Ana M.; Simões, SandraA multistep and diversity-oriented synthetic route aiming at the A3 coupling/domino cyclization of o-ethynyl anilines, aldehydes and s-amines is described. The preparation of the corresponding precursors included a series of transformations, such as haloperoxidation and Sonogashira cross-coupling reactions, amine protection, desilylation and amine reduction. Some products of the multicomponent reaction underwen...
Facile access to structurally diverse antimalarial indoles using a one‐pot A3 c...
Silva, Gustavo Da; Luz, André F. S.; Duarte, Denise; Fontinha, Diana; Silva, Vera L. M.; Almeida Paz, Filipe A.; Madureira, Ana MargaridaA multistep and diversity-oriented synthetic route aiming at the A3 coupling/domino cyclization of o-ethynyl anilines, aldehydes and s-amines is described. The preparation of the corresponding precursors included a series of transformations, such as haloperoxidation and Sonogashira cross-coupling reactions, amine protection, desilylation and amine reduction. Some products of the multicomponent reaction underwen...
The Champions in life and social networks
Moreira, RuiOne of the characteristics that makes any artist immortal is his ability to produce timeless art. The genius of Fernando Pessoa, world-renowned poet, is manifested in the "Poem in straight line" of his heteronym, Alvaro de Campos.Fernando Pessoa manages, in a poem written about 100 years ago, to paint a perfect portrait of the virtual reality that we live in social networks today. It is absolutely astounding to...
Quinolin-(1H)-imines as a new chemotype against leishmaniasis: biological evalu...
Alves, Ana G. Gomes; Duarte, Margarida; Cruz, Tânia; Castro, Helena; Lopes, Francisca; Moreira, Rui; Ressurreição, Ana S.; Tomás, Ana M.Leishmaniasis is one of the most challenging neglected tropical diseases and remains a global threat to public health. Currently available therapies for leishmaniases present significant drawbacks and are rendered increasingly inefficient due to parasite resistance, urging the need for more effective, safer, and cheaper drugs. In our efforts to identify novel chemical scaffolds for the development of antileishm...
Recovery of depleted miR-146a in ALS cortical astrocytes reverts cell aberranci...
Barbosa, Marta; Gomes, Cátia; Sequeira, Catarina; Gonçalves-Ribeiro, Joana; Pina, Carolina Campos; Carvalho, Luís A.; Moreira, Rui; Vaz, Sandra H.Reactive astrocytes in Amyotrophic Lateral Sclerosis (ALS) change their molecular expression pattern and release toxic factors that contribute to neurodegeneration and microglial activation. We and others identified a dysregulated inflammatory miRNA profile in ALS patients and in mice models suggesting that they represent potential targets for therapeutic intervention. Such cellular miRNAs are known to be relea...