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Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, ...

Boonstra, André; Rajsbaum, Ricardo; Holman, Mary; Marques, Rute; Asselin-Paturel, Carine; Pereira, João Pedro; Bates, Elizabeth E. M.; Akira, Shizuo

We have previously reported that mouse plasmacytoid dendritic cells (DC) produce high levels of IL-12p70, whereas bone marrow-derived myeloid DC and splenic DC produce substantially lower levels of this cytokine when activated with the TLR-9 ligand CpG. We now show that in response to CpG stimulation, high levels of IL-10 are secreted by macrophages, intermediate levels by myeloid DC, but no detectable IL-10 is...

Date: 2006   |   Origin: RepositóriUM - Universidade do Minho
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