11 documents found, page 1 of 2
Appraising animal models of prostate cancer for translational research: future ...
Nascimento-Gonçalves, E; Seixas, F; Gil da Costa, R; Pires, MJ; Neuparth, MJ; Moreira-Gonçalves, D; Fardilha, M; Faustino-Rocha, Ana I; Colaço, BThe growing incidence of prostate cancer has prompted a great investment in basic biology and translational studies to develop new therapies. Multiple animal models have been established to study etiological factors, cancer-preventive strategies and the molecular determinants of aggressiveness and metastases. The rat model of prostate cancer induced by chemical carcinogen N-methyl-N-nitrosourea (MNU) and testos...
Lifelong exercise training promotes the remodelling of the immune system and pr...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJ; Moreira-Gonçalves, DThis work aimed to understand how lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of PCa. Fifty-five male Wistar rats were divided into four groups: control sedentary, control exercised, induced PCa sedentary and induced PCa exercised. Exercised animals were trained in a treadmill for 53 weeks. Pca induction consisted on the sequential administratio...
Moderate intensity treadmill exercise influences the immune system and prostate...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJMaterial & Methods: Fifty-five male Wistar rats were divided into: control sedentary (SED+CONT; n=10), control exercised (EX+CONT; n=10), induced sedentary (SED+PCa; n=15), and induced exercised (EX+PCa; n=20). Exercised animals were trained in a treadmill, for 53 weeks. PCa induction consisted of flutamide and N-methyl-N-nitrosourea administration, followed by testosterone propionate implants. At sacrifice, pr...
Immune system and prostate signalome in a rat model of prostate cancer: influen...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJImmune system and prostate signalome in a rat model of prostate cancer: influence of lifelong exercise training
Unveiling the role of moderate exercise training in immune system and prostate ...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJBackground: Prostate cancer (PCa) is among the most prevalent cancers worldwide. This work aimed to under- stand the effects of exercise training in a rat model of PCa chemically and hormonally-induced. Material and Methods: Fifty-five male Wistar rats were divided into: control sedentary (SED+CONT; n=10), control exercised (EX+CONT; n=10), induced seden- tary (SED+PCa; n = 15) and induced exercised (EX+PCa; n=...
Moderate intensity treadmill exercise influences the immune system and prostate...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJMODERATE INTENSITY TREADMILL EXERCISE INFLUENCES THE IMMUNE SYSTEM AND PROSTATE SIGNALOME IN A RAT MODEL OF PROSTATE CANCER
Immune system and prostate signalome in a rat model of prostate cancer: influen...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJImmune system and prostate signalome in a rat model of prostate cancer: influence of lifelong exercise training
Effects of physical exercise in biochemical parameters and dorsolateral prostat...
Nascimento-Gonçalves, E; Seixas, F; Faustino-Rocha, AI; Pires, MJ; Neuparth, MJ; Moreira-Gonçalves, D; Duarte, JA; Colaço, B; Ferreira, R; Oliveira, PABackground: Prostate cancer (PCa) is among the most prevalent cancers worldwide. Physical exercise is widely recognized due to its beneficial effects. This study aimed to evaluate the effects of physical exercise on biochemical pa- rameters and in dorsolateral prostate lesions in a rat model of PCa. Materials and Methods: Ninety-five male Wistar Unilever rats were randomly divided into eight groups sacrificed a...
Exercise training impacts cardiac mitochondrial proteome remodeling in murine u...
Ferreira, R; Neuparth, M; Nogueira-Ferreira, R; Magalhães, S; Aroso, M; Bovolini, J; Santos, L; Oliveira, P; Vitorino, R; Moreira-Gonçalves, DCardiac dysfunction secondary to cancer may exert a negative impact in patients’ tolerance to therapeutics, quality of life, and survival. The aim of this study was to evaluate the potential therapeutic effect of exercise training on the heart in the setting of cancer, after diagnosis. Thus, the molecular pathways harbored in heart mitochondria from a murine model of chemically-induced urothelial carcinoma subm...
Anti-remodeling effects of xanthohumol-fortified beer in pulmonary arterial hyp...
Silva, AF; Faria-Costa, G; Sousa-Nunes, F; Santos, MF; Ferreira-Pinto, MJ; Duarte, D; Rodrigues, I; Guimarães, JT; Leite-Moreira, APolyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) would be able to ...