3 documents found, page 1 of 1
Pharmacological NF-κB inhibition decreases cisplatin chemoresistance in muscle-...
Gil da Costa, Rui; Levesque, C; Bianchi-Frias D; Chatterjee, P; Lam, HM; Santos, C; Coleman, IM; Ferreirinha, P; Vilanova, M; Pinto da Cunha, NMost patients with muscle-invasive bladder cancer (MIBC) are not cured with platinum chemotherapy. Up-regulation of nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) is a major mechanism underlying chemoresistance, suggesting that its pharmacological inhibition may increase platinum efficacy. NF-κB signaling was investigated in two patient cohorts. The Cancer Genome Atlas (TCGA) was used to...
Characterizing the molecular and physiological changes associated with colorect...
Silva-Reis, R; Faustino-Rocha, Ana I; Castro-Ribeiro, C; Gonçalves, M; Ferreira, T; Pires, MJ; Iglesias- Aguierre, CE; Cortés-Martín, A; Selma, MVCharacterizing the molecular and physiological changes associated with colorectal cancer in wistar rats
An integrative approach to characterize the early phases of dimethylhydrazine-i...
Silva-Reis, Carla; Castro-Ribeiro, C; Gonçalves, M; Ferreira, T; Pires, MJ; Iglesias-Aguirre, CE; Cortés-Martín, A; Selma, MV; Espín, JCThis study aimed to characterize an animal model of colorectal cancer (CRC) in the early stages of disease development. Twenty-nine male Wistar rats were divided into two control groups (CTRL1 and CTRL2), receiving EDTA–saline injections and two induced groups (CRC1 and CRC2), receiving 1,2-dimethylhydrazine (DMH) injections for seven consecutive weeks. CRC1 and CTRL1 were euthanized at the 11th week, while CRC...