4 documents found, page 1 of 1
All the pups we cannot see: Cannibalism masks perinatal death in laboratory mou...
Brajon, S; Morello, GM; Capas-Peneda, S; Hultgren, J; Gilbert, C; Olsson, IASPerinatal mortality is a major issue in laboratory mouse breeding. We compared a counting method using daily checks (DAILY_CHECK) with a method combining daily checks with detailed video analyses to detect cannibalisms (VIDEO_TRACK) for estimating the number of C57BL/6 pups that were born, that died and that were weaned in 193 litters from trios with (TRIOOVERLAP) or without (TRIO-NO_OVERLAP) the presence of an...
Necropsy protocol for newborn mice
Capas-Peneda, S; Morello, GM; Lamas, S; Olsson, IAS; Gilbert, CNeonatal mortality is high in laboratory mouse breeding, and causes are poorly understood. Post-mortem analysis of pups is an often overlooked source of information and insight. We present a necropsy protocol for neonatal mice designed for easy practical application by animal technicians.
High laboratory mouse pre-weaning mortality associated with litter overlap, adv...
Morello, GM; Hultgren, J; Capas-Peneda, S; Wiltshire, M; Thomas, A; Wardle-Jones, H; Brajon, S; Gilbert, C; Olsson, IASHigh and variable pre-weaning mortality is a persistent problem in laboratory mouse breeding. Assuming a modest 15% mortality rate across mouse strains, means that approximately 1 million more pups are produced yearly in the EU to compensate for those which die. This paper presents the first large study under practical husbandry conditions to determine the risk factors associated with mouse pre-weaning mortalit...
Does training method matter? Evidence for the negative impact of aversive-based...
Castro, ACV; Fuchs, D; Morello, GM; Pastur, S; Sousa, L; Olsson, IASDog training methods range broadly from those using mostly positive punishment and negative reinforcement (aversive-based) to those using primarily positive reinforcement (rewardbased). Although aversive-based training has been strongly criticized for negatively affecting dog welfare, there is no comprehensive research focusing on companion dogs and mainstream techniques, and most studies rely on owner-reported...