2 documents found, page 1 of 1
Long-term predictive accuracy of the ‘mild cognitive impairment due to Alzheime...
Cardoso, Sandra; Montalvo, Alexandre; Maroco, João; Silva, Dina; Alves, Luísa; Guerreiro, Manuela; de Mendonça, AlexandreFunding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The work was in part funded by the project, Ref. COMPETE2030-FEDER-00707500, co-funded by (COMPETE2030), and the European Union, and by National Funds through Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia, I.P. The authors thank Memocl\u00EDnica for the ...
A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic ...
Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, NunoPublisher Copyright: Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.; In Alzheimer's disease (AD), amyloid β (Aβ)-triggered cleavage of TrkB-FL impairs brain-derived neurotrophic factor (BDNF) signaling, thereby compromising neuronal survival, differentiation, and synaptic transmission and plasticity. Using cerebrospinal fluid and postmortem human brain samples, we show that TrkB...