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Icariin stimulates differentiation of bone marrow-derived mesenchymal stem cell...

Lou, Dan; Ye, Jifeng; Yang, Lianhua; Wu, Zheng; Zheng, Wei; Zhang, Hui

Icariin, a prenylated flavonol glycoside isolated from Epimedium, has been considered as a potential alternative therapy for osteoporosis. The present study aimed to clarify the detailed molecular mechanisms of action of icariin on osteoblast function, using bone marrow-derived mesenchymal stem cells (BM‑MSCs). BM-MSCs were first stimulated by icariin. Then, gene and protein expression of cAMP/ PKA/CREB signali...

Date: 2019   |   Origin: Oasisbr
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