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Delivery of Antisense Oligonucleotides Mediated by a Hydrogel System: In Vitro ...

Moreno, PMD; Rodrigues, T; Torrado, M; Amaral, IF; Pêgo, AP

Biomaterials-based hydrogels are attractive drug-eluting vehicles in the context of RNA therapeutics, such as those utilizing antisense oligonucleotide or RNA interference based drugs, as they can potentially reduce systemic toxicity and enhance in vivo efficacy by increasing in situ concentrations. Here we describe the preparation of antisense oligonucleotide-loaded fibrin hydrogels exploring their application...

Date: 2019   |   Origin: Repositório Aberto da Universidade do Porto
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