8 documents found, page 1 of 1
Acute Kidney Injury and Electrolyte Imbalances Caused by Dapagliflozin Short-Te...
Lopes, António Cabral; Lourenço, Olga; Morgado, Sandra; Gaspar, Andreia; Freire, Idalina; Eusébio, Inês; Ribeiro, João; Silva, Mafalda; Mendes, MartaDapagliflozin, a sodium–glucose cotransporter 2 inhibitor (SGLT2i), has shown demonstrated benefits for renal and cardiovascular outcomes in large clinical trials. However, short-term concerns regarding its impact on renal function and electrolyte balance exist. This study aimed to evaluate the short-term effects of dapagliflozin on renal function and electrolyte balance in patients newly prescribed the medicat...
Nutritional Risk Screening in Children with Cerebral Palsy
Mendes, Inês Curvelo; Carvalho, Rita; Asseiceira, Inês; Mendes, Armando; Morgado, Sandra; Amaral, Raquel; Sousa, Isabel; Sousa, JoanaIntroduction: Validated and practical tools for nutritional risk screening are essential for the early recognition of children who would benefit from a complete nutritional assessment and subsequent nutritional interventions. In this regard, this study aimed to apply different nutritional risk screening tools for children with cerebral palsy and recognize the most appropriate tool. Methods: In total, 30 childre...
Management of the Adverse Effects of Immune Checkpoint Inhibitors
Morgado, Manuel; Plácido, Ana; Morgado, Sandra; Roque, FátimaBy increasing the activity of the immune system, immune checkpoint inhibitors (ICPI) can have adverse inflammatory effects, which are referred to as immune-related adverse effects (irAEs). In this review, we present the recommendations for the appropriate identification and treatment of irAEs associated with ICPI to increase the safety and effectiveness of therapy with these immuno-oncological drugs. Several gu...
Behavioral Sciences in the Optimization of Pharmacological and Non-Pharmacologi...
Lopes, António; Roque, Fátima; Morgado, Sandra; Dinis, CristinaType 2 diabetes mellitus is one of the main chronic diseases worldwide, with a significant impact on public health. Behavioral changes are an important step in disease prevention and management, so the way in which individuals adapt their lifestyle to new circumstances will undoubtedly be a predictor of the success of the treatments instituted, contributing to a reduction in the morbidity and mortality that may...
Arbutus unedo L.: From traditional medicine to potential uses in modern pharmac...
Morgado, Sandra; Morgado, Manuel; Plácido, Ana; Roque, Fátima; Duarte, Ana PaulaEthnopharmacological relevance: Arbutus unedo L., the strawberry tree (Ericaceae family) is of increasing interest because of its common traditional, industrial, chemical and pharmaceutical uses. The plant is a typical evergreen plant of the Mediterranean basin, as well as of other regions with hot summers and mild rainy winters. This review covers the studies relevant to Arbutus unedo L. utilization in the cur...
INIBIDORES DAS TIROSINACINASES NA TERAPÊUTICA FARMACOLÓGICA
Saraiva, Sara; Morgado, Sandra; Morgado, ManuelThe discovery of mutations in tyrosine kinases (TKs) involved in the pathogenesis of many diseases, particularly oncological, encouraged the investigation of inhibitors of tyrosine kinases (ITKs) as therapeutic strategies.The aim of this study was to perform a review of the different ITKs available in the national and international markets, their therapeutic indications, and their potential directions in resear...
INIBIDORES DAS FOSFODIESTERASES DOS NUCLEÓTIDOS CÍCLICOS NA TERAPÊUTICA FARMACO...
Morgado, Sandra; Morgado, Manuel; Costa, Isabel MargaridaCyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers adenosine 3´5´-cyclic monophosphate (cAMP) and guanosine 3´5´-cyclic monophosphate (cGMP) by controlling their rates of degradation. The increase of intracellular levels of cAMP and cGMP, through PDE inhibition, represents a useful strategy for eliciting a variety of pharmacological effects with im...
Pharmacist interventions to enhance blood pressure control and adherence to ant...
Morgado, Manuel; Morgado, Sandra; Mendes, Liliana; Pereira, L.; Castelo-Branco, MiguelPurpose. Pharmacist interventions to enhance blood pressure (BP) control and adherence to antihypertensive therapy in adults with essential hypertension were reviewed. Methods. A literature search was conducted to identify relevant articles describing pharmacist interventions intended to improve adherence to antihypertensive medications. Studies were included if they described a pharmacist intervention to impro...