4 documents found, page 1 of 1
Impact of early surgery and immunosuppression on Crohn's disease disabling outc...
Magro, Fernando; Dias, Cláudia C.; Coelho, Rosa; Santos, Paula M.; Fernandes, Samuel; Caetano, Cidalina; Rodrigues, Angela; Portela, FranciscoBackground and Aims: The definition of early therapeutic strategies to control Crohn's disease aggressiveness and prevent recurrence is key to improve clinical practice. This study explores the impact of early surgery and immunosuppression onset in the occurrence of disabling outcomes. Methods: This was a multicentric and retrospective study with 754 patients with Crohn's disease, who were stratified according ...
Development and validation of risk matrices for Crohn's Disease outcomes in pat...
Dias, Cláudia Camila; Rodrigues, Pedro Pereira; Coelho, Rosa; Santos, Paula Moura; Fernandes, Samuel; Lago, Paula; Caetano, Cidalina; Rodrigues, AngelaIntroduction: The establishment of prognostic models for Crohn's disease [CD] is highly desirable, as they have the potential to guide physicians in the decision-making process concerning therapeutic choices, thus improving patients' health and quality of life. Our aim was to derive models for disabling CD and reoperation based solely on clinical/demographic data. Methods: A multicentric and retrospectively enr...
The who-when-why triangle of complementary and alternative medicine use among P...
Portela, Francisco; Dias, Camila C.; Caldeira, Paulo; Cravo, Marilia; Deus, João; Gonçalves, Raquel; Lago, Paula; Morna, Henrique; Peixe, PaulaBackground: The use of complementary and alternative medicines is increasing among chronic patients, particularly those afflicted with inflammatory bowel diseases. Aim: This study aimed to address the prevalence of complementary and alternative medicines use among Portuguese inflammatory bowel diseases' patients. Methods: Patients were invited to fill an anonymous questionnaire concerning the use of complementa...
Germline MUTYH (MYH) mutations in portuguese individuals with multiple colorect...
Isidro, Glória; Laranjeira, Francisco; Pires, Ana; Leite, Júlio; Regateiro, Fernando; Sousa, F. Castro; Soares, José; Castro, Clara; Giria, JoãoGerminal mutations in the base excision repair (BER) gene MUTYH (MYH) have recently been described in association with predisposition to multiple colorectal adenomas and cancer. In contrast to the classic dominant condition of familial adenomatous polyposis (FAP) due to germinal mutations in the APC gene, the MYH polyposis is an autosomal recessive disease. The identification of individuals affected by MYH poly...