19 documents found, page 1 of 2
Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-mot...
Servelhere,Katiane R.; Faber,Ingrid; Martinez,Alberto; Nickel,Renato; Moro,Adriana; Germiniani,Francisco M. B.; Moscovich,Mariana; Blume,Tatiane R.ABSTRACT Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms in HSP patients. Objective To assess the efficacy of Btx-A on motor and non-motor manifestations in HSP patients. Methods...
Apomorphine in the treatment of Parkinson's disease: a review
Pessoa,Renata Ramina; Moro,Adriana; Munhoz,Renato Puppi; Teive,Hélio A.G.; Lees,Andrew J.ABSTRACT Optimizing idiopathic Parkinson's disease treatment is a challenging, multifaceted and continuous process with direct impact on patients’ quality of life. The basic tenet of this task entails tailored therapy, allowing for optimal motor function with the fewest adverse effects. Apomorphine, a dopamine agonist used as rescue therapy for patients with motor fluctuations, with potential positive effects o...
A tragédia da talidomida: a luta pelos direitos das vítimas e por melhor regula...
Moro,Adriana; Invernizzi,NoelaResumo A tragédia da talidomida, no final dos anos 1950, constituiu um divisor de águas na regulação de medicamentos. Novos usos da droga estão sendo pesquisados e implementados atualmente. O artigo revisita a história da talidomida e seus desdobramentos no plano regulatório e dos direitos das vítimas no Brasil, com base em revisão de literatura, análise documental e reportes de jornais. Destaca que os eventos ...
Treatment of hemifacial spasm with botulinum toxin type a: effective, long last...
Batisti,Jean Pierre Mette; Kleinfelder,Alais Daiane Fadini; Galli,Natália Bassalobre; Moro,Adriana; Munhoz,Renato Puppi; Teive,Hélio Afonso GhizoniABSTRACT Hemifacial spasm (HFS) is a common movement disorder characterized by involuntary tonic or clonic contractions of the muscles innervated by the facial nerve. Objective To evaluate the long-term effect of botulinum toxin type A (BTX-A) in the treatment of HFS. Methods A retrospective analysis of patients treated at the Movement Disorders Outpatient Clinic in the Neurology Service, Hospital de Clínicas, ...
Increased sexual arousal in patients with movement disorders
Teive,Hélio A. G.; Moro,Adriana; Moscovich,Mariana; Munhoz,Renato P.ABSTRACT Increased of sexual arousal (ISA) has been described in different neurological diseases. The purpose of this study was present a case series of ISA in patients with movement disorders. Method Fifteen patients with different forms of movement disorders (Parkinson’s disease, Huntington’s disease, Tourette´s syndrome, spinocerebellar ataxia type 3), were evaluated in the Movement Disorders Unit of the Fed...
Itajaí, Santa Catarina – Azorean ancestry and spinocerebellar ataxia type 3
Teive,Hélio A. G.; Moro,Adriana; Arruda,Walter O.; Raskin,Salmo; Teive,Gladys M. G.; Dallabrida,Norberto; Munhoz,Renato P.ABSTRACT The authors present a historical review of spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD), the most common form of spinocerebellar ataxia in Brazil, and consider the high frequency of cases in families from Itajaí, a city on the coast of the state of Santa Catarina with a large population of Portuguese/Azorean descent.
Cognitive impairment in Spinocerebellar ataxia type 10
Moro,Adriana; Teive,Hélio Afonso GhizoniABSTRACT Background: Cognitive and psychiatric dysfunction has been described in several neurodegenerative diseases but has not been systematically evaluated in spinocerebellar ataxia type 10 (SCA10). Objective: The aim of the present study was to investigate the core cognitive features in a large cohort of Brazilian patients with SCA10, comparing the results against a healthy control group. Methods: Twenty-eig...
Spinocerebellar ataxia type 10 in the South of Brazil: the Amerindian-Belgian c...
Teive,Hélio Afonso Ghizoni; Moro,Adriana; Moscovich,Mariana; Arruda,Walter Oleskho; Munhoz,Renato Puppi; Raskin,Salmo; Teive,Gladys Mary GhizoniSpinocerebellar ataxia type 10 (SCA10) is a rare form of autosomal dominant ataxia found predominantly in patients from Latin America with Amerindian ancestry. The authors report the history of SCA10 families from the south of Brazil (the states of Paraná and Santa Catarina), emphasizing the Belgian-Amerindian connection.
Idiopathic very late-onset cerebellar ataxia: a Brazilian case series
Teive,Hélio A. G.; Moscovich,Mariana; Moro,Adriana; Farah,Marina; Arruda,Walter O.; Munhoz,Renato P.ABSTRACTThe authors present a Brazilian case series of eight patients with idiopathic very-late onset (mean 75.5 years old) cerebellar ataxia, featuring predominantly gait ataxia, associated with cerebellar atrophy.Method: 26 adult patients with a diagnosis of idiopathic late onset cerebellar ataxia were analyzed in a Brazilian ataxia outpatient clinic and followed regularly over 20 years. Among them, 8 elderly...
Non-motor signs in Parkinson’s disease: a review
Munhoz,Renato P.; Moro,Adriana; Silveira-Moriyama,Laura; Teive,Helio A.During the past decade the view of Parkinson’s disease (PD) as a motor disorder has changed significantly and currently it is recognized as a multisystem process with diverse non-motor signs (NMS). In addition to been extremely common, these NMS play a major role in undermining functionality and quality of life. On the other hand, NMS are under recognized by physicians and neglected by patients. Here, we review...